Nanodiamonds as a platform for targeted delivery of chlorin-based photosensitizers to cancer cells

D. A. Gvozdev; Ramonova; Y. B. Slonimskiy; V. R. Gudkova; E. I. Nikelshparg; A. Moisenovich; Moisenovich; A. V. Zaitsev; V. A. Olshevskaya; V. Z. Paschenko; G. Maksimov

doi:10.1016/j.diamond.2021.108676

Nanodiamonds as a platform for targeted delivery of chlorin-based photosensitizers to cancer cells

D. A. Gvozdev
, Ramonova
, Y. B. Slonimskiy
, V. R. Gudkova
, E. I. Nikelshparg
, A. Moisenovich
, Moisenovich
, A. V. Zaitsev
, V. A. Olshevskaya
, V. Z. Paschenko
, G. Maksimov

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Targeted delivery of photosensitizers is one of the main problems of the photodynamic therapy of cancer. Nanodiamonds hold much promise as a delivery platform because of their good sorption properties, functionally modifiable surfaces, and low biological toxicity of carbon. In this work, we present a rational design of nanodiamonds for targeted delivery of boronated derivative of e6 chloride to human A431 epidermoid carcinoma cells. Formation of hybrid complexes in aqueous solution is accompanied by deactivation of the excited states of the dye. This prevents generation of reactive oxygen species until the complex reaches the target. In the presence of lipid membranes, the photosensitizers leave the complex and exhibit their photodynamic activity. Modification of the nanodiamond surface by transferrin leads to an additional increase in the efficiency of photodynamic inactivation of cancer cells.

Original language	English
Article number	108676
Journal	Diamond and Related Materials
Volume	120
DOIs	https://doi.org/10.1016/j.diamond.2021.108676
State	Published - 1 Dec 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Nanodiamonds
Photobleaching
Photosensitizer
Targeted delivery
Transferrin

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Mechanical Engineering
General Physics and Astronomy
Materials Chemistry
Electrical and Electronic Engineering

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10.1016/j.diamond.2021.108676

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Gvozdev, D. A., Ramonova, Slonimskiy, Y. B., Gudkova, V. R., Nikelshparg, E. I., Moisenovich, A., Moisenovich, Zaitsev, A. V., Olshevskaya, V. A., Paschenko, V. Z., & Maksimov, G. (2021). Nanodiamonds as a platform for targeted delivery of chlorin-based photosensitizers to cancer cells. Diamond and Related Materials, 120, Article 108676. https://doi.org/10.1016/j.diamond.2021.108676

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title = "Nanodiamonds as a platform for targeted delivery of chlorin-based photosensitizers to cancer cells",

abstract = "Targeted delivery of photosensitizers is one of the main problems of the photodynamic therapy of cancer. Nanodiamonds hold much promise as a delivery platform because of their good sorption properties, functionally modifiable surfaces, and low biological toxicity of carbon. In this work, we present a rational design of nanodiamonds for targeted delivery of boronated derivative of e6 chloride to human A431 epidermoid carcinoma cells. Formation of hybrid complexes in aqueous solution is accompanied by deactivation of the excited states of the dye. This prevents generation of reactive oxygen species until the complex reaches the target. In the presence of lipid membranes, the photosensitizers leave the complex and exhibit their photodynamic activity. Modification of the nanodiamond surface by transferrin leads to an additional increase in the efficiency of photodynamic inactivation of cancer cells.",

keywords = "Nanodiamonds, Photobleaching, Photosensitizer, Targeted delivery, Transferrin",

author = "Gvozdev, \{D. A.\} and Ramonova and Slonimskiy, \{Y. B.\} and Gudkova, \{V. R.\} and Nikelshparg, \{E. I.\} and A. Moisenovich and Moisenovich and Zaitsev, \{A. V.\} and Olshevskaya, \{V. A.\} and Paschenko, \{V. Z.\} and G. Maksimov",

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year = "2021",

month = dec,

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doi = "10.1016/j.diamond.2021.108676",

language = "English",

volume = "120",

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AU - Gvozdev, D. A.

AU - Ramonova,

AU - Slonimskiy, Y. B.

AU - Gudkova, V. R.

AU - Nikelshparg, E. I.

AU - Moisenovich, A.

AU - Moisenovich,

AU - Zaitsev, A. V.

AU - Olshevskaya, V. A.

AU - Paschenko, V. Z.

AU - Maksimov, G.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Targeted delivery of photosensitizers is one of the main problems of the photodynamic therapy of cancer. Nanodiamonds hold much promise as a delivery platform because of their good sorption properties, functionally modifiable surfaces, and low biological toxicity of carbon. In this work, we present a rational design of nanodiamonds for targeted delivery of boronated derivative of e6 chloride to human A431 epidermoid carcinoma cells. Formation of hybrid complexes in aqueous solution is accompanied by deactivation of the excited states of the dye. This prevents generation of reactive oxygen species until the complex reaches the target. In the presence of lipid membranes, the photosensitizers leave the complex and exhibit their photodynamic activity. Modification of the nanodiamond surface by transferrin leads to an additional increase in the efficiency of photodynamic inactivation of cancer cells.

AB - Targeted delivery of photosensitizers is one of the main problems of the photodynamic therapy of cancer. Nanodiamonds hold much promise as a delivery platform because of their good sorption properties, functionally modifiable surfaces, and low biological toxicity of carbon. In this work, we present a rational design of nanodiamonds for targeted delivery of boronated derivative of e6 chloride to human A431 epidermoid carcinoma cells. Formation of hybrid complexes in aqueous solution is accompanied by deactivation of the excited states of the dye. This prevents generation of reactive oxygen species until the complex reaches the target. In the presence of lipid membranes, the photosensitizers leave the complex and exhibit their photodynamic activity. Modification of the nanodiamond surface by transferrin leads to an additional increase in the efficiency of photodynamic inactivation of cancer cells.

KW - Nanodiamonds

KW - Photobleaching

KW - Photosensitizer

KW - Targeted delivery

KW - Transferrin

UR - https://www.scopus.com/pages/publications/85118533684

U2 - 10.1016/j.diamond.2021.108676

DO - 10.1016/j.diamond.2021.108676

M3 - Article

AN - SCOPUS:85118533684

SN - 0925-9635

VL - 120

JO - Diamond and Related Materials

JF - Diamond and Related Materials

M1 - 108676

ER -

Nanodiamonds as a platform for targeted delivery of chlorin-based photosensitizers to cancer cells

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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