Nanoengineered Antiviral Fibrous Arrays with Rose-Thorn-Inspired Architectures

Amir Nasajpour; Mohamadmahdi Samandari; Chandrashekhar D. Patil; Reza Abolhassani; Rahul K. Suryawanshi; Rainer Adelung; Horst Günter Rubahn; Ali Khademhosseini; Yogendra Kumar Mishra; Deepak Shukla; Ali Tamayol; Paul S. Weiss

doi:10.1021/acsmaterialslett.1c00419

Nanoengineered Antiviral Fibrous Arrays with Rose-Thorn-Inspired Architectures

Amir Nasajpour, Mohamadmahdi Samandari, Chandrashekhar D. Patil, Reza Abolhassani, Rahul K. Suryawanshi, Rainer Adelung, Horst Günter Rubahn, Ali Khademhosseini, Yogendra Kumar Mishra, Deepak Shukla, Ali Tamayol, Paul S. Weiss

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Herpes simplex virus (HSV) plagues billions of humans with infections globally. We have developed and demonstrated rose-thorn-inspired antiviral fibrous arrays by electrospinning a composite of polycaprolactone (PCL) polymer with a dispersion of anisotropic zinc oxide tetrapod nanoparticles (ZOTeN). This rose-thorn-mimicking material enables physical and chemical protection. Under blue-light stimulation, ZOTeN photocatalyzes the production of hydrogen peroxide for an accessible disinfection and sterilizing mechanism to prolong materials usage. Using scanning electron microscopy and X-ray photoelectron spectroscopy, we confirm the rose-thorn-inspired morphology and the chemical composition, respectively. The fibrous material has dose-dependent antiviral properties against both HSV-1 and HSV-2. The engineered mats can potentially be used for manufacturing antiviral garments, face coverings, and bandages.

Original language	English
Pages (from-to)	1566-1571
Number of pages	6
Journal	ACS Materials Letters
Volume	3
Issue number	11
DOIs	https://doi.org/10.1021/acsmaterialslett.1c00419
State	Published - 1 Nov 2021
Externally published	Yes

ASJC Scopus subject areas

General Chemical Engineering
Biomedical Engineering
General Materials Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsmaterialslett.1c00419

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title = "Nanoengineered Antiviral Fibrous Arrays with Rose-Thorn-Inspired Architectures",

abstract = "Herpes simplex virus (HSV) plagues billions of humans with infections globally. We have developed and demonstrated rose-thorn-inspired antiviral fibrous arrays by electrospinning a composite of polycaprolactone (PCL) polymer with a dispersion of anisotropic zinc oxide tetrapod nanoparticles (ZOTeN). This rose-thorn-mimicking material enables physical and chemical protection. Under blue-light stimulation, ZOTeN photocatalyzes the production of hydrogen peroxide for an accessible disinfection and sterilizing mechanism to prolong materials usage. Using scanning electron microscopy and X-ray photoelectron spectroscopy, we confirm the rose-thorn-inspired morphology and the chemical composition, respectively. The fibrous material has dose-dependent antiviral properties against both HSV-1 and HSV-2. The engineered mats can potentially be used for manufacturing antiviral garments, face coverings, and bandages.",

author = "Amir Nasajpour and Mohamadmahdi Samandari and Patil, {Chandrashekhar D.} and Reza Abolhassani and Suryawanshi, {Rahul K.} and Rainer Adelung and Rubahn, {Horst G{\"u}nter} and Ali Khademhosseini and Mishra, {Yogendra Kumar} and Deepak Shukla and Ali Tamayol and Weiss, {Paul S.}",

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AU - Nasajpour, Amir

AU - Samandari, Mohamadmahdi

AU - Patil, Chandrashekhar D.

AU - Abolhassani, Reza

AU - Suryawanshi, Rahul K.

AU - Adelung, Rainer

AU - Rubahn, Horst Günter

AU - Khademhosseini, Ali

AU - Mishra, Yogendra Kumar

AU - Shukla, Deepak

AU - Tamayol, Ali

AU - Weiss, Paul S.

PY - 2021/11/1

Y1 - 2021/11/1

N2 - Herpes simplex virus (HSV) plagues billions of humans with infections globally. We have developed and demonstrated rose-thorn-inspired antiviral fibrous arrays by electrospinning a composite of polycaprolactone (PCL) polymer with a dispersion of anisotropic zinc oxide tetrapod nanoparticles (ZOTeN). This rose-thorn-mimicking material enables physical and chemical protection. Under blue-light stimulation, ZOTeN photocatalyzes the production of hydrogen peroxide for an accessible disinfection and sterilizing mechanism to prolong materials usage. Using scanning electron microscopy and X-ray photoelectron spectroscopy, we confirm the rose-thorn-inspired morphology and the chemical composition, respectively. The fibrous material has dose-dependent antiviral properties against both HSV-1 and HSV-2. The engineered mats can potentially be used for manufacturing antiviral garments, face coverings, and bandages.

AB - Herpes simplex virus (HSV) plagues billions of humans with infections globally. We have developed and demonstrated rose-thorn-inspired antiviral fibrous arrays by electrospinning a composite of polycaprolactone (PCL) polymer with a dispersion of anisotropic zinc oxide tetrapod nanoparticles (ZOTeN). This rose-thorn-mimicking material enables physical and chemical protection. Under blue-light stimulation, ZOTeN photocatalyzes the production of hydrogen peroxide for an accessible disinfection and sterilizing mechanism to prolong materials usage. Using scanning electron microscopy and X-ray photoelectron spectroscopy, we confirm the rose-thorn-inspired morphology and the chemical composition, respectively. The fibrous material has dose-dependent antiviral properties against both HSV-1 and HSV-2. The engineered mats can potentially be used for manufacturing antiviral garments, face coverings, and bandages.

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U2 - 10.1021/acsmaterialslett.1c00419

DO - 10.1021/acsmaterialslett.1c00419

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VL - 3

SP - 1566

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JO - ACS Materials Letters

JF - ACS Materials Letters

IS - 11

ER -

Nanoengineered Antiviral Fibrous Arrays with Rose-Thorn-Inspired Architectures

Abstract

ASJC Scopus subject areas

UN SDGs

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