TY - JOUR
T1 - Nanoengineered Peptide-Based Antimicrobial Conductive Supramolecular Biomaterial for Cardiac Tissue Engineering
AU - Chakraborty, Priyadarshi
AU - Oved, Hadas
AU - Bychenko, Darya
AU - Yao, Yifei
AU - Tang, Yiming
AU - Zilberzwige-Tal, Shai
AU - Wei, Guanghong
AU - Dvir, Tal
AU - Gazit, Ehud
N1 - Publisher Copyright:
© 2021 Wiley-VCH GmbH
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Owing to their dynamic nature and ordered architecture, supramolecular materials strikingly resemble organic components of living systems. Although short-peptide self-assembled nanostructured hydrogels are regarded as intriguing supramolecular materials for biotechnology, their application is often limited due to their low stability and considerable challenge of combining other desirable properties. Herein, a di-Fmoc-based hydrogelator containing the cell-adhesive Arg–Gly–Asp (RGD) fragment that forms a mechanically stable, self-healing hydrogel is designed. Molecular dynamics simulation reveals the presence of RGD segments on the surface of the hydrogel fibers, highlighting their cell adherence capacity. Aiming to impart conductivity, the 3D network of the hydrogel is further nanoengineered by incorporating polyaniline (PAni). The composite hydrogels demonstrate semiconductivity, excellent antibacterial activity, and DNA binding capacity. Cardiac cells grown on the surface of the composite hydrogels form functional synchronized monolayers. Taken together, the combination of these attributes in a single hydrogel suggests it as an exceptional candidate for functional supramolecular biomaterial designed for electrogenic tissue engineering.
AB - Owing to their dynamic nature and ordered architecture, supramolecular materials strikingly resemble organic components of living systems. Although short-peptide self-assembled nanostructured hydrogels are regarded as intriguing supramolecular materials for biotechnology, their application is often limited due to their low stability and considerable challenge of combining other desirable properties. Herein, a di-Fmoc-based hydrogelator containing the cell-adhesive Arg–Gly–Asp (RGD) fragment that forms a mechanically stable, self-healing hydrogel is designed. Molecular dynamics simulation reveals the presence of RGD segments on the surface of the hydrogel fibers, highlighting their cell adherence capacity. Aiming to impart conductivity, the 3D network of the hydrogel is further nanoengineered by incorporating polyaniline (PAni). The composite hydrogels demonstrate semiconductivity, excellent antibacterial activity, and DNA binding capacity. Cardiac cells grown on the surface of the composite hydrogels form functional synchronized monolayers. Taken together, the combination of these attributes in a single hydrogel suggests it as an exceptional candidate for functional supramolecular biomaterial designed for electrogenic tissue engineering.
KW - antibacterial properties
KW - biomaterials
KW - cardiac tissue engineering
KW - hydrogels
KW - peptides
KW - polyaniline
UR - http://www.scopus.com/inward/record.url?scp=85106248053&partnerID=8YFLogxK
U2 - 10.1002/adma.202008715
DO - 10.1002/adma.202008715
M3 - Article
C2 - 34033154
AN - SCOPUS:85106248053
SN - 0935-9648
VL - 33
JO - Advanced Materials
JF - Advanced Materials
IS - 26
M1 - 2008715
ER -