Nanoparticle-Assisted Stimulated-Emission-Depletion Nanoscopy

Yonatan Sivan; Yannick Sonnefraud; Stéphane Kéna-Cohen; John B. Pendry; Stefan A. Maier

doi:10.1021/nn301082g

Nanoparticle-Assisted Stimulated-Emission-Depletion Nanoscopy

Yonatan Sivan, Yannick Sonnefraud, Stéphane Kéna-Cohen, John B. Pendry, Stefan A. Maier

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Figure Persented: We show that metal nanoparticles can be used to improve the performance of super-resolution fluorescence nanoscopes based on stimulated-emission-depletion (STED). Compared with a standard STED nanoscope, we show theoretically a resolution improvement by more than an order of magnitude, or equivalently, depletion intensity reductions by more than 2 orders of magnitude and an even stronger photostabilization. Our scheme may allow improvement of existing STED nanoscopes and assist in the development of low-power, low-cost nanoscopes. This has the potential to increase the availability of STED nanoscopes and lead to a significant expansion of our understanding of biological and biochemical phenomena occurring on the nanoscale.

Original language	English
Pages (from-to)	5291-5296
Number of pages	6
Journal	ACS Nano
Volume	6
Issue number	6
DOIs	https://doi.org/10.1021/nn301082g
State	Published - 26 Jun 2012
Externally published	Yes

Keywords

STED microscopy
nanoshells
photobleaching
plasmonics
super-resolution
triplets

ASJC Scopus subject areas

Materials Science (all)
Engineering (all)
Physics and Astronomy (all)

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10.1021/nn301082g

Cite this

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abstract = "Figure Persented: We show that metal nanoparticles can be used to improve the performance of super-resolution fluorescence nanoscopes based on stimulated-emission-depletion (STED). Compared with a standard STED nanoscope, we show theoretically a resolution improvement by more than an order of magnitude, or equivalently, depletion intensity reductions by more than 2 orders of magnitude and an even stronger photostabilization. Our scheme may allow improvement of existing STED nanoscopes and assist in the development of low-power, low-cost nanoscopes. This has the potential to increase the availability of STED nanoscopes and lead to a significant expansion of our understanding of biological and biochemical phenomena occurring on the nanoscale.",

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T1 - Nanoparticle-Assisted Stimulated-Emission-Depletion Nanoscopy

AU - Sivan, Yonatan

AU - Sonnefraud, Yannick

AU - Kéna-Cohen, Stéphane

AU - Pendry, John B.

AU - Maier, Stefan A.

PY - 2012/6/26

Y1 - 2012/6/26

N2 - Figure Persented: We show that metal nanoparticles can be used to improve the performance of super-resolution fluorescence nanoscopes based on stimulated-emission-depletion (STED). Compared with a standard STED nanoscope, we show theoretically a resolution improvement by more than an order of magnitude, or equivalently, depletion intensity reductions by more than 2 orders of magnitude and an even stronger photostabilization. Our scheme may allow improvement of existing STED nanoscopes and assist in the development of low-power, low-cost nanoscopes. This has the potential to increase the availability of STED nanoscopes and lead to a significant expansion of our understanding of biological and biochemical phenomena occurring on the nanoscale.

AB - Figure Persented: We show that metal nanoparticles can be used to improve the performance of super-resolution fluorescence nanoscopes based on stimulated-emission-depletion (STED). Compared with a standard STED nanoscope, we show theoretically a resolution improvement by more than an order of magnitude, or equivalently, depletion intensity reductions by more than 2 orders of magnitude and an even stronger photostabilization. Our scheme may allow improvement of existing STED nanoscopes and assist in the development of low-power, low-cost nanoscopes. This has the potential to increase the availability of STED nanoscopes and lead to a significant expansion of our understanding of biological and biochemical phenomena occurring on the nanoscale.

KW - STED microscopy

KW - nanoshells

KW - photobleaching

KW - plasmonics

KW - super-resolution

KW - triplets

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Nanoparticle-Assisted Stimulated-Emission-Depletion Nanoscopy

Abstract

Keywords

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