Nanotheranostic Applications for Detection and Targeting Neurodegenerative Diseases

Ajay Kumar, Ravi Kumar Chaudhary, Rachita Singh, Satya P. Singh, Shao Yu Wang, Zheng Yu Hoe, Cheng Tang Pan, Yow Ling Shiue, Dong Qing Wei, Aman Chandra Kaushik, Xiaofeng Dai

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

Nanotechnology utilizes engineered materials and devices which function with biological systems at the molecular level and could transform the management of neurodegenerative diseases (NDs) by provoking, reacting to, and intermingling with target sites to stimulate physiological responses while minimizing side effects. Blood–brain barrier (BBB) protects the brain from harmful agents, and transporting drugs across the BBB is a major challenge for diagnosis, targeting, and treatment of NDs. The BBB provides severe limitations for diagnosis and treatment of Alzheimer’s disease (AD), Parkinson’s disease (PD), and various other neurological diseases. Conventional drug delivery systems generally fail to cross the BBB, thus are inefficient in treatment. Although gradual development through research is ensuring the progress of nanotheranostic approaches from animal to human modeling, aspects of translational applicability and safety are a key concern. This demands a deep understanding of the interaction of body systems with nanomaterials. There are various plant-based nanobioactive compounds which are reported to have applicability in the diagnosis and treatment of these NDs. This review article provides an overview of applications of nanotheranostics in AD and PD. The review also discusses nano-enabled drug delivery systems and their current and potential applications for the treatment of various NDs.

Original languageEnglish
Article number305
JournalFrontiers in Neuroscience
Volume14
DOIs
StatePublished - 30 Apr 2020
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • Parkinson’s disease
  • nanocomposite
  • nanotheranostics
  • neurodegenerative disorders

ASJC Scopus subject areas

  • General Neuroscience

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