TY - JOUR
T1 - Naringin Attenuates the Diabetic Neuropathy in STZ-Induced Type 2 Diabetic Wistar Rats
AU - Ahmad, Md Fahim
AU - Naseem, Nida
AU - Rahman, Inamur
AU - Imam, Nazia
AU - Younus, Hina
AU - Pandey, Swaroop Kumar
AU - Siddiqui, Waseem A.
N1 - Funding Information:
All the authors sincerely thankful to the Coordinator, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, for providing necessary facilities. M.F.A. highly acknowledges the Indian Council of Medical Research (ICMR), New Delhi, for providing the Senior Research Fellowship (SRF), and N.N. for availing the JRF from the ICMR.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - The application of traditional medicines for the treatment of diseases, including diabetic neuropathy (DN), has received great attention. The aim of this study was to investigate the ameliorative potential of naringin, a flavanone, to treat streptozotocin-induced DN in rat models. After the successful induction of diabetes, DN complications were measured by various behavioral tests after 4 weeks of post-induction of diabetes with or without treatment with naringin. Serum biochemical assays such as fasting blood glucose, HbA1c%, insulin, lipid profile, and oxidative stress parameters were determined. Proinflammatory cytokines such as TNF-α and IL-6, and neuron-specific markers such as BDNF and NGF, were also assessed. In addition, pancreatic and brain tissues were subjected to histopathology to analyze structural alterations. The diabetic rats exhibited increased paw withdrawal frequencies for the acetone drop test and decreased frequencies for the plantar test, hot plate test, and tail flick test. The diabetic rats also showed an altered level of proinflammatory cytokines and oxidative stress parameters, as well as altered levels of proinflammatory cytokines and oxidative stress parameters. Naringin treatment significantly improved these parameters and helped in restoring the normal architecture of the brain and pancreatic tissues. The findings show that naringin’s neuroprotective properties may be linked to its ability to suppress the overactivation of inflammatory molecules and mediators of oxidative stress.
AB - The application of traditional medicines for the treatment of diseases, including diabetic neuropathy (DN), has received great attention. The aim of this study was to investigate the ameliorative potential of naringin, a flavanone, to treat streptozotocin-induced DN in rat models. After the successful induction of diabetes, DN complications were measured by various behavioral tests after 4 weeks of post-induction of diabetes with or without treatment with naringin. Serum biochemical assays such as fasting blood glucose, HbA1c%, insulin, lipid profile, and oxidative stress parameters were determined. Proinflammatory cytokines such as TNF-α and IL-6, and neuron-specific markers such as BDNF and NGF, were also assessed. In addition, pancreatic and brain tissues were subjected to histopathology to analyze structural alterations. The diabetic rats exhibited increased paw withdrawal frequencies for the acetone drop test and decreased frequencies for the plantar test, hot plate test, and tail flick test. The diabetic rats also showed an altered level of proinflammatory cytokines and oxidative stress parameters, as well as altered levels of proinflammatory cytokines and oxidative stress parameters. Naringin treatment significantly improved these parameters and helped in restoring the normal architecture of the brain and pancreatic tissues. The findings show that naringin’s neuroprotective properties may be linked to its ability to suppress the overactivation of inflammatory molecules and mediators of oxidative stress.
KW - diabetes mellitus
KW - diabetic neuropathy
KW - histopathology
KW - naringin
KW - neuronal specific markers
KW - proinflammatory cytokines
KW - streptozotocin
UR - http://www.scopus.com/inward/record.url?scp=85144894008&partnerID=8YFLogxK
U2 - 10.3390/life12122111
DO - 10.3390/life12122111
M3 - Article
C2 - 36556476
AN - SCOPUS:85144894008
SN - 2075-1729
VL - 12
JO - Life
JF - Life
IS - 12
M1 - 2111
ER -
