Nasopharyngeal colonization in Southern Israel with antibiotic-resistant pneumococci during the first 2 years of life: Relation to serotypes likely to be included in pneumococcal conjugate vaccines

Ron Dagan, Rimma Melamed, Marie Muallem, Lolita Piglansky, Pablo Yagupsky

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

Nasopharyngeal carriage of Streptococcus pneumoniae was studied in 162 healthy infants at ages 2, 4, 6, 7, 12, and 13 months and in an additional 352 healthy children at ages 12, 15, 18, 21, and 24 months. Carriage was 26%, 39%, and 62% at 2, 12, and 24 months, respectively, and the respective resistance to ≤1 antibiotic was 11%, 19%, and 27%. The presence of an older sibling or antibiotic treatment during the month preceding the culture was associated with carriage of resistant pneumococci in infants, whereas attendance at large day care centers was associated with carriage during the second year of life. Antibiotic resistance was detected in all 7 serotypes included in the candidate pediatric conjugate vaccines and was significantly more prevalent among vaccine-type pneumococci than among non-vaccine-type pneumococci. The use of conjugate vaccines may reduce the spread of resistant pneumococci.

Original languageEnglish
Pages (from-to)1352-1355
Number of pages4
JournalJournal of Infectious Diseases
Volume174
Issue number6
DOIs
StatePublished - 1 Jan 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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