Abstract
Natural products derived from living organisms have vast potential in pharmaceuticals, agrochemicals, and various industries due to their intricate structures and biological activities. These natural products play crucial roles in organisms and serve as medicines, colorants, and supplements in human diets. Efforts to optimize these compounds have led to research focusing on engineering pathways in plants. However, traditional extraction methods from plants are laborious and unsustainable. Therefore, engineered microbial hosts offer sustainable solutions employing synthetic biology. Understanding plant biosynthetic pathways is pivotal for engineering, while microbial systems require a delicate balance for efficient compound expression. Recent advancements in engineering metabolic pathways within microbial hosts have transformed natural product biosynthesis. These systems offer precise control and sustainability, leveraging the natural synthesis capabilities of bacteria and fungi for various applications. This chapter explores the emerging field of natural product biosynthesis in engineered microbial hosts, showcasing recent advancements and their potential to revolutionize compound production.
| Original language | English |
|---|---|
| Title of host publication | Medicinal Biotechnology |
| Subtitle of host publication | Methods and Applications |
| Publisher | Elsevier |
| Pages | 223-250 |
| Number of pages | 28 |
| ISBN (Electronic) | 9780443222641 |
| ISBN (Print) | 9780443222658 |
| DOIs | |
| State | Published - 1 Jan 2024 |
Keywords
- Engineering microbial hosts
- Flavonoids synthesis
- Microbial hosts
- Natural products
- Pathway engineering
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
