Natural products as mediators of disease

Neha Garg; Tal Luzzatto-Knaan; Alexey V. Melnik; Andrés Mauricio Caraballo-Rodríguez; Dimitrios J. Floros; Daniel Petras; Rachel Gregor; Pieter C. Dorrestein; Vanessa V. Phelan

doi:10.1039/c6np00063k

Natural products as mediators of disease

Neha Garg, Tal Luzzatto-Knaan, Alexey V. Melnik, Andrés Mauricio Caraballo-Rodríguez, Dimitrios J. Floros, Daniel Petras, Rachel Gregor, Pieter C. Dorrestein, Vanessa V. Phelan

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

Original language	English
Pages (from-to)	194-219
Number of pages	26
Journal	Natural Product Reports
Volume	34
Issue number	2
DOIs	https://doi.org/10.1039/c6np00063k
State	Published - 1 Feb 2017

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c6np00063k

Cite this

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title = "Natural products as mediators of disease",

abstract = "Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.",

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AU - Garg, Neha

AU - Luzzatto-Knaan, Tal

AU - Melnik, Alexey V.

AU - Caraballo-Rodríguez, Andrés Mauricio

AU - Floros, Dimitrios J.

AU - Petras, Daniel

AU - Gregor, Rachel

AU - Dorrestein, Pieter C.

AU - Phelan, Vanessa V.

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AB - Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

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Natural products as mediators of disease

Abstract

ASJC Scopus subject areas

UN SDGs

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