TY - JOUR
T1 - Natural products as mediators of disease
AU - Garg, Neha
AU - Luzzatto-Knaan, Tal
AU - Melnik, Alexey V.
AU - Caraballo-Rodríguez, Andrés Mauricio
AU - Floros, Dimitrios J.
AU - Petras, Daniel
AU - Gregor, Rachel
AU - Dorrestein, Pieter C.
AU - Phelan, Vanessa V.
N1 - Funding Information:
This work was partially supported by the National Institutes of Health (NIH) Grants 5P41GM103484 (PCD), AI095125 (PCD), GM097509 (PCD), GM094802 (PCD), GM107550 (PCD), S10R029121 (PCD), K01 GM103809 (VVP), the European Union 7th Framework Programme grant 305259 (PCD) and the L.S. Skaggs Professorship (VVP). TLK is supported by the United States - Israel Binational Agricultural Research and Development Fund Vaadia-BARD No. FI-494-13. AMCR is supported by São Paulo Research Foundation (FAPESP) grant #2014/01651-8, 2012/21803-1. DF is supported by NIH Training Grant T32EB009380
Publisher Copyright:
© 2017 The Royal Society of Chemistry.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.
AB - Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.
UR - http://www.scopus.com/inward/record.url?scp=85012074236&partnerID=8YFLogxK
U2 - 10.1039/c6np00063k
DO - 10.1039/c6np00063k
M3 - Review article
C2 - 27874907
AN - SCOPUS:85012074236
SN - 0265-0568
VL - 34
SP - 194
EP - 219
JO - Natural Product Reports
JF - Natural Product Reports
IS - 2
ER -
