Near fatal acute colchicine intoxication in a child. A case report

Aviv Goldbart; Joseph Press; Shaul Sofer; Joseph Kapelushnik

doi:10.1007/PL00008364

Near fatal acute colchicine intoxication in a child. A case report

Aviv Goldbart, Joseph Press, Shaul Sofer, Joseph Kapelushnik

Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug. She developed gastrointestinal, central nervous system, cardiovascular and haematological disturbances. Over 2 months she had been drinking high doses of natural grapefruit juice which, combined with long-term colchicine therapy and a viral upper respiratory tract infection, increased her susceptibility to the drug. Conclusion: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.

Original language	English
Pages (from-to)	895-897
Number of pages	3
Journal	European Journal of Pediatrics
Volume	159
Issue number	12
DOIs	https://doi.org/10.1007/PL00008364
State	Published - 1 Jan 2000

Keywords

Colchicine intoxication
Familial Mediterranean fever
Grapefruit juice

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1007/PL00008364

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abstract = "An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug. She developed gastrointestinal, central nervous system, cardiovascular and haematological disturbances. Over 2 months she had been drinking high doses of natural grapefruit juice which, combined with long-term colchicine therapy and a viral upper respiratory tract infection, increased her susceptibility to the drug. Conclusion: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.",

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AB - An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug. She developed gastrointestinal, central nervous system, cardiovascular and haematological disturbances. Over 2 months she had been drinking high doses of natural grapefruit juice which, combined with long-term colchicine therapy and a viral upper respiratory tract infection, increased her susceptibility to the drug. Conclusion: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.

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KW - Grapefruit juice

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Near fatal acute colchicine intoxication in a child. A case report

Abstract

Keywords

ASJC Scopus subject areas

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