Negative Impact of Disorders of Gut-Brain Interaction on Health-Related Quality of Life: Results From the Rome Foundation Global Epidemiology Survey

Simon R. Knowles, David Skvarc, Alexander C. Ford, Olafur S. Palsson, Shrikant I. Bangdiwala, Ami D. Sperber, Antonina Mikocka-Walus

    Research output: Contribution to journalArticlepeer-review

    14 Scopus citations

    Abstract

    Background & Aims: This study used the database from the Rome Foundation Global Epidemiology Survey to assess the differences in quality of life overall, and by age and sex, across individual disorders of gut-brain interaction (DGBI), gastrointestinal anatomical region(s), and number of overlapping DGBI. Methods: Data were collected via the Internet in 26 countries, using the Rome IV diagnostic questionnaire and a supplemental questionnaire including the Patient-Reported Outcomes Measurement Information Systems Global-10 quality of life measure. Factorial analyses of variance were used to explore physical and mental quality of life, adjusting for multiple comparisons. Results: Among the 54,127 respondents, quality of life deteriorated significantly with increasing number of overlapping DGBI, with respondents reporting ≥2 DGBI having significantly poorer quality of life than those with only 1 DGBI or those without any DGBI. Men with DGBI reported better quality of life than women, and those aged ≥65 years reported better quality of life than those <65 years. Age, sex, number of overlapping DGBI, somatization, anxiety, depression, and functional experiences (concern, embarrassment, or stress associated with bowel functioning) relating to DGBI, were significant predictors of poorer physical and mental quality of life. Conclusions: This study is the most comprehensive assessment of quality of life to date in adults living with a DGBI. It provides a representative picture of DGBI impact on adults in the global adult population and highlights the significant detrimental impact of living with a DGBI on quality of life.

    Original languageEnglish
    Pages (from-to)655-668.e10
    JournalGastroenterology
    Volume164
    Issue number4
    DOIs
    StatePublished - 1 Apr 2023

    Keywords

    • Age
    • Disorders of Gut-Brain Interaction
    • Mental Health
    • Quality of Life
    • Sex

    ASJC Scopus subject areas

    • Gastroenterology
    • Hepatology

    Fingerprint

    Dive into the research topics of 'Negative Impact of Disorders of Gut-Brain Interaction on Health-Related Quality of Life: Results From the Rome Foundation Global Epidemiology Survey'. Together they form a unique fingerprint.

    Cite this