Negative impact of 'old-to-old' donations on success of cadaveric renal transplants

Inbal Weiss-Salz, Micha Mandel, Noya Galai, Geoffrey Boner, Eytan Mor, Richard Nakache, Elisheva Simchen, Tamar Ashkenazi, Ahmed Eid, Jonathan Halevi, Aaron Hoffman, Ron Loewenthal, Solly Mizrahi, Ruth Rahamimov, Anat Rotem, Moshe Shabtai

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations

    Abstract

    The effect of 'old-to-old' cadaveric renal transplants on operative complications and graft survival was assessed in all 325 patients undergoing solitary cadaveric renal transplantations in Israel during a 3-yr period. Preoperative information and hospital course data were abstracted from the charts. Results were analyzed using Kaplan-Meyer survival curves, univariate and multivariate Cox models. Overall, 62 (19.1%) grafts failed within a year. Failure rate was 46.2% for 'old-to-old' transplants compared with 15.5% for all other donor/recipient age combinations (p < 0.0001). 'Old-to-old' transplants remained independently associated with graft failure in a multivariate Cox model after controlling the effect of other risk factors. 'Old-to-old' transplants were also associated with increased operative complications relative to other age combinations. The decision to use 'old-to-old' transplants, even when donors are scarce, is problematic and should be reconsidered.

    Original languageEnglish
    Pages (from-to)372-376
    Number of pages5
    JournalClinical Transplantation
    Volume19
    Issue number3
    DOIs
    StatePublished - 1 Jun 2005

    Keywords

    • 'Old-to-old' transplants
    • Cadaveric kidney transplant
    • Graft failure
    • Operative complications

    ASJC Scopus subject areas

    • Transplantation

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