Neoangiogenesis in squamous cell carcinoma of the larynx - Biological and prognostic associations

Netta Sion-Vardy; Dan M. Fliss; Isebrand Prinsloo; Ilana Shoham-Vardi; Daniel Benharroch

doi:10.1078/0344-0338-00001

Neoangiogenesis in squamous cell carcinoma of the larynx - Biological and prognostic associations

Netta Sion-Vardy, Dan M. Fliss, Isebrand Prinsloo, Ilana Shoham-Vardi, Daniel Benharroch

The International Center of Health Innovation & Nutrition in memory of Manya Igel

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Tumor angiogenesis has been related to tumor growth and an increased probability of metastatic spread. Previous studies have led to conflicting views regarding the prognostic significance of angiogenesis in squamous cell carcinoma of the head and neck. To evaluate the role of tumor angiogenesis in the biology of squamous cell carcinoma of the larynx, we quantified the microvascular network in 59 primary laryngeal carcinomas and looked for an association with outcome. Microvessels were stained immunohistochemically using antibodies for factor VIII-related antigen and the antibody JC70 (CD-31). In each case, microvessels were counted in three fields at ×200 magnification, in areas of most intense neovascularization. We found a significantly higher number of microvessels in tumors showing deeper levels of invasion.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Pathology Research and Practice
Volume	197
Issue number	1
DOIs	https://doi.org/10.1078/0344-0338-00001
State	Published - 1 Jan 2001

Keywords

Angiogenesis
Depth of invasion
Lymph node metastasis
Squamous cell carcinoma

ASJC Scopus subject areas

Pathology and Forensic Medicine
Cell Biology

Access to Document

10.1078/0344-0338-00001

Cite this

@article{b515eb463a1546608d38dd725c108cf8,

title = "Neoangiogenesis in squamous cell carcinoma of the larynx - Biological and prognostic associations",

abstract = "Tumor angiogenesis has been related to tumor growth and an increased probability of metastatic spread. Previous studies have led to conflicting views regarding the prognostic significance of angiogenesis in squamous cell carcinoma of the head and neck. To evaluate the role of tumor angiogenesis in the biology of squamous cell carcinoma of the larynx, we quantified the microvascular network in 59 primary laryngeal carcinomas and looked for an association with outcome. Microvessels were stained immunohistochemically using antibodies for factor VIII-related antigen and the antibody JC70 (CD-31). In each case, microvessels were counted in three fields at ×200 magnification, in areas of most intense neovascularization. We found a significantly higher number of microvessels in tumors showing deeper levels of invasion.",

keywords = "Angiogenesis, Depth of invasion, Lymph node metastasis, Squamous cell carcinoma",

author = "Netta Sion-Vardy and Fliss, {Dan M.} and Isebrand Prinsloo and Ilana Shoham-Vardi and Daniel Benharroch",

year = "2001",

month = jan,

day = "1",

doi = "10.1078/0344-0338-00001",

language = "English",

volume = "197",

pages = "1--5",

journal = "Pathology Research and Practice",

issn = "0344-0338",

publisher = "Urban und Fischer Verlag GmbH und Co. KG",

number = "1",

}

TY - JOUR

T1 - Neoangiogenesis in squamous cell carcinoma of the larynx - Biological and prognostic associations

AU - Sion-Vardy, Netta

AU - Fliss, Dan M.

AU - Prinsloo, Isebrand

AU - Shoham-Vardi, Ilana

AU - Benharroch, Daniel

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Tumor angiogenesis has been related to tumor growth and an increased probability of metastatic spread. Previous studies have led to conflicting views regarding the prognostic significance of angiogenesis in squamous cell carcinoma of the head and neck. To evaluate the role of tumor angiogenesis in the biology of squamous cell carcinoma of the larynx, we quantified the microvascular network in 59 primary laryngeal carcinomas and looked for an association with outcome. Microvessels were stained immunohistochemically using antibodies for factor VIII-related antigen and the antibody JC70 (CD-31). In each case, microvessels were counted in three fields at ×200 magnification, in areas of most intense neovascularization. We found a significantly higher number of microvessels in tumors showing deeper levels of invasion.

AB - Tumor angiogenesis has been related to tumor growth and an increased probability of metastatic spread. Previous studies have led to conflicting views regarding the prognostic significance of angiogenesis in squamous cell carcinoma of the head and neck. To evaluate the role of tumor angiogenesis in the biology of squamous cell carcinoma of the larynx, we quantified the microvascular network in 59 primary laryngeal carcinomas and looked for an association with outcome. Microvessels were stained immunohistochemically using antibodies for factor VIII-related antigen and the antibody JC70 (CD-31). In each case, microvessels were counted in three fields at ×200 magnification, in areas of most intense neovascularization. We found a significantly higher number of microvessels in tumors showing deeper levels of invasion.

KW - Angiogenesis

KW - Depth of invasion

KW - Lymph node metastasis

KW - Squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0035136764&partnerID=8YFLogxK

U2 - 10.1078/0344-0338-00001

DO - 10.1078/0344-0338-00001

M3 - Article

C2 - 11209811

AN - SCOPUS:0035136764

SN - 0344-0338

VL - 197

SP - 1

EP - 5

JO - Pathology Research and Practice

JF - Pathology Research and Practice

IS - 1

ER -

Neoangiogenesis in squamous cell carcinoma of the larynx - Biological and prognostic associations

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this