Neoangiogenesis in squamous cell carcinoma of the larynx - Biological and prognostic associations

Netta Sion-Vardy, Dan M. Fliss, Isebrand Prinsloo, Ilana Shoham-Vardi, Daniel Benharroch

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Tumor angiogenesis has been related to tumor growth and an increased probability of metastatic spread. Previous studies have led to conflicting views regarding the prognostic significance of angiogenesis in squamous cell carcinoma of the head and neck. To evaluate the role of tumor angiogenesis in the biology of squamous cell carcinoma of the larynx, we quantified the microvascular network in 59 primary laryngeal carcinomas and looked for an association with outcome. Microvessels were stained immunohistochemically using antibodies for factor VIII-related antigen and the antibody JC70 (CD-31). In each case, microvessels were counted in three fields at ×200 magnification, in areas of most intense neovascularization. We found a significantly higher number of microvessels in tumors showing deeper levels of invasion.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalPathology Research and Practice
Issue number1
StatePublished - 1 Jan 2001


  • Angiogenesis
  • Depth of invasion
  • Lymph node metastasis
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology


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