Nephrotic syndrome associated with transitional cell carcinoma of the bladder

J. Rapoport, O. Kuperman, Y. Gopas, E. Maor, A. Eyal, M. Mostovslavski, A. Abuful, C. Chaimovitz

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We describe the occurrence of a nephrotic syndrome in association with transitional cell carcinoma of the bladder. The proteinuria disappeared several weeks after removal of the tumor. Light and electron microscopy were compatible with a minimal-change lesion, but immunofluorescence showed linear immunoglobulin deposition. Immunoglobulins eluted from the tumor reacted specifically with the kidney and vice versa. We conclude that antibody formation against a specific component of basement membrane common to both kidney and tumor gave rise to the nephropathy in this case.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalNephron
Volume52
Issue number1
DOIs
StatePublished - 1 Jan 1989
Externally publishedYes

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