Network Modeling of Tissues and Cell Types

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary


All cellular processes, from cell growth and proliferation to metabolism and cell death, involve biochemical interactions among genes, proteins, RNA, metabolites, and other molecules. In specific cellular contexts, such as within a cellular compartment, cell type, or tissue, certain molecular interactions occur whereas other interactions are avoided, resulting in distinct cellular processes, functions and phenotypes. Network concepts, algorithms and tools allow for modeling and predicting how the molecular interactions combine into cellular processes in distinct contexts. This article presents network approaches and their application to the modeling of tissues and cell types, with particular emphasis on modeling human tissues.

Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology
Subtitle of host publicationSystems, Translational and Specialized Cell Aspects of Cell Biology
Number of pages10
EditionSecond Edition
ISBN (Electronic)9780128216248
StatePublished - 2023


  • Bioinformatics
  • Data Integration
  • Gene Expression
  • Human Tissues
  • Interaction Networks
  • Network Biology
  • Protein-Protein Interactions
  • RNA Sequencing
  • Single Cell
  • Tissue Specificity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)


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