TY - JOUR
T1 - Neural-endocrine-immune complex in the central modulation of tumorigenesis
T2 - Facts, assumptions, and hypotheses
AU - Mravec, Boris
AU - Gidron, Yori
AU - Kukanova, Barbara
AU - Bizik, Jozef
AU - Kiss, Alexander
AU - Hulin, Ivan
N1 - Funding Information:
The authors thank MD. Peter Ujhazy, PhD for valuable contributions. This work was supported by Grant of Comenius University UK/40/2006.
PY - 2006/11/1
Y1 - 2006/11/1
N2 - For the precise coordination of systemic functions, the nervous system uses a variety of peripherally and centrally localized receptors, which transmit information from internal and external environments to the central nervous system. Tight interconnections between the immune, nervous, and endocrine systems provide a base for monitoring and consequent modulation of immune system functions by the brain and vice versa. The immune system plays an important role in tumorigenesis. On the basis of rich interconnections between the immune, nervous and endocrine systems, the possibility that the brain may be informed about tumorigenesis is discussed in this review article. Moreover, the eventual modulation of tumorigenesis by central nervous system is also considered. Prospective consequences of the interactions between tumor and brain for diagnosis and therapy of cancer are emphasized.
AB - For the precise coordination of systemic functions, the nervous system uses a variety of peripherally and centrally localized receptors, which transmit information from internal and external environments to the central nervous system. Tight interconnections between the immune, nervous, and endocrine systems provide a base for monitoring and consequent modulation of immune system functions by the brain and vice versa. The immune system plays an important role in tumorigenesis. On the basis of rich interconnections between the immune, nervous and endocrine systems, the possibility that the brain may be informed about tumorigenesis is discussed in this review article. Moreover, the eventual modulation of tumorigenesis by central nervous system is also considered. Prospective consequences of the interactions between tumor and brain for diagnosis and therapy of cancer are emphasized.
KW - Autonomic nervous system
KW - Brain
KW - Cytokines
KW - Tumorigenesis
KW - Vagus nerve
UR - http://www.scopus.com/inward/record.url?scp=33750614749&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2006.07.003
DO - 10.1016/j.jneuroim.2006.07.003
M3 - Article
C2 - 16945428
AN - SCOPUS:33750614749
VL - 180
SP - 104
EP - 116
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -
