Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates

J. Tal, M. T. Price, J. W. Olney

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Systemic administration of excitatory amino acids (Glu or NMA) rapidly enhances LH release (rodents or primates) and GABA blocks this action (rodents). In the present study rodent and primate pituitaries were incubated with NMA, Glu and/or GABA, with or without added LH-RH. Only LH-RH affected LH release. Therefore the probable site of NMA, Glu or GABA action on LH release in both rodents and primates is suprapituitary.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalBrain Research
Volume273
Issue number1
DOIs
StatePublished - 22 Aug 1983
Externally publishedYes

Keywords

  • GABA
  • N-methylaspartate (NMA)
  • arcuate hypothalamic nucleus (AH)
  • glutamate (Glu)
  • luteinizing hormone-releasing hormone (LH-RH)
  • neuroactive amino acids
  • suprapituitary mechanism

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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