Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates

J. Tal; M. T. Price; J. W. Olney

doi:10.1016/0006-8993(83)91110-1

Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates

J. Tal
, M. T. Price
, J. W. Olney

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Systemic administration of excitatory amino acids (Glu or NMA) rapidly enhances LH release (rodents or primates) and GABA blocks this action (rodents). In the present study rodent and primate pituitaries were incubated with NMA, Glu and/or GABA, with or without added LH-RH. Only LH-RH affected LH release. Therefore the probable site of NMA, Glu or GABA action on LH release in both rodents and primates is suprapituitary.

Original language	English
Pages (from-to)	179-182
Number of pages	4
Journal	Brain Research
Volume	273
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(83)91110-1
State	Published - 22 Aug 1983
Externally published	Yes

Keywords

GABA
N-methylaspartate (NMA)
arcuate hypothalamic nucleus (AH)
glutamate (Glu)
luteinizing hormone-releasing hormone (LH-RH)
neuroactive amino acids
suprapituitary mechanism

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(83)91110-1

Cite this

@article{28fb0487932b436cbc8f8738d8e6f7bd,

title = "Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates",

abstract = "Systemic administration of excitatory amino acids (Glu or NMA) rapidly enhances LH release (rodents or primates) and GABA blocks this action (rodents). In the present study rodent and primate pituitaries were incubated with NMA, Glu and/or GABA, with or without added LH-RH. Only LH-RH affected LH release. Therefore the probable site of NMA, Glu or GABA action on LH release in both rodents and primates is suprapituitary.",

keywords = "GABA, N-methylaspartate (NMA), arcuate hypothalamic nucleus (AH), glutamate (Glu), luteinizing hormone-releasing hormone (LH-RH), neuroactive amino acids, suprapituitary mechanism",

author = "J. Tal and Price, \{M. T.\} and Olney, \{J. W.\}",

year = "1983",

month = aug,

day = "22",

doi = "10.1016/0006-8993(83)91110-1",

language = "English",

volume = "273",

pages = "179--182",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates

AU - Tal, J.

AU - Price, M. T.

AU - Olney, J. W.

PY - 1983/8/22

Y1 - 1983/8/22

N2 - Systemic administration of excitatory amino acids (Glu or NMA) rapidly enhances LH release (rodents or primates) and GABA blocks this action (rodents). In the present study rodent and primate pituitaries were incubated with NMA, Glu and/or GABA, with or without added LH-RH. Only LH-RH affected LH release. Therefore the probable site of NMA, Glu or GABA action on LH release in both rodents and primates is suprapituitary.

AB - Systemic administration of excitatory amino acids (Glu or NMA) rapidly enhances LH release (rodents or primates) and GABA blocks this action (rodents). In the present study rodent and primate pituitaries were incubated with NMA, Glu and/or GABA, with or without added LH-RH. Only LH-RH affected LH release. Therefore the probable site of NMA, Glu or GABA action on LH release in both rodents and primates is suprapituitary.

KW - GABA

KW - N-methylaspartate (NMA)

KW - arcuate hypothalamic nucleus (AH)

KW - glutamate (Glu)

KW - luteinizing hormone-releasing hormone (LH-RH)

KW - neuroactive amino acids

KW - suprapituitary mechanism

UR - https://www.scopus.com/pages/publications/0020638259

U2 - 10.1016/0006-8993(83)91110-1

DO - 10.1016/0006-8993(83)91110-1

M3 - Article

C2 - 6137263

AN - SCOPUS:0020638259

SN - 0006-8993

VL - 273

SP - 179

EP - 182

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this