Neurodevelopmental factors associated with schizotypal symptoms among adolescents at risk for schizophrenia

Sydney L. Hans, Judith G. Auerbach, Keith H. Nuechterlein, Robert F. Asarnow, Joan Asarnow, Benedict Styr, Joseph Marcus

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Schizophrenia has come to be viewed as a neurodevelopmental disorder that is characterized by genetic vulnerability, stressors during the prenatal period that may be marked by minor physical anomalies and neurobehavioral deficits that emerge in early development. Less is known about the neurodevelopmental origins of schizotypal personality symptoms. The present study examines schizotypal symptoms in Israeli adolescents (mean age = 16.79 years) who have not yet reached the developmental period during which first schizophrenic episode is most likely to emerge: 39 adolescent offspring of parents with schizophrenia, 39 offspring of parents with other psychiatric disorders, and 36 offspring of parents with no history of mental illness. The Semi-Structured Kiddie Interview for Personality Syndromes was used to assess cognitiveperceptual, interpersonal, and disorganized schizotypal symptoms. Interpersonal schizotypal symptoms were more prevalent in the schizophrenia offspring group than in the no-mental-illness offspring group. Among the schizophrenia offspring group, interpersonal, but not cognitiveperceptual, schizotypal symptoms were associated with minor physical anomalies, fine motor dyscoordination, and deficits in executive functioning during adolescence. Among young people whose parents did not have schizophrenia, cognitiveperceptual schizotypal symptoms were correlated with deficits in executive functioning. Adolescent schizotypal symptoms were associated with neurobehavioral symptoms measured during middle childhood in a subgroup of the sample that had been assessed prospectively. Finally, young people who had genetic risk for schizophrenia, minor physical anomalies, and neurobehavioral signs together were at markedly increased risk for symptoms of interpersonal schizotypal symptoms, compared to young people with one or none of these risk factors.

Original languageEnglish
Pages (from-to)1195-1210
Number of pages16
JournalDevelopment and Psychopathology
Volume21
Issue number4
DOIs
StatePublished - 1 Jan 2009

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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