Neuroinflammation in Alzheimer disease

Michael T. Heneka; Wiesje M. van der Flier; Frank Jessen; Jeroen Hoozemanns; Dietmar Rudolf Thal; Delphine Boche; Frederic Brosseron; Charlotte Teunissen; Henrik Zetterberg; Andreas H. Jacobs; Paul Edison; Alfredo Ramirez; Carlos Cruchaga; Jean Charles Lambert; Agustin Ruiz Laza; Jose Vicente Sanchez-Mut; Andre Fischer; Sergio Castro-Gomez; Thor D. Stein; Luca Kleineidam; Michael Wagner; Jonas J. Neher; Colm Cunningham; Sim K. Singhrao; Marco Prinz; Christopher K. Glass; Johannes C.M. Schlachetzki; Oleg Butovsky; Kilian Kleemann; Philip L. De Jaeger; Hannah Scheiblich; Guy C. Brown; Gary Landreth; Miguel Moutinho; Jaime Grutzendler; Diego Gomez-Nicola; Róisín M. McManus; Katrin Andreasson; Christina Ising; Deniz Karabag; Darren J. Baker; Shane A. Liddelow; Alexei Verkhratsky; Malu Tansey; Alon Monsonego; Ludwig Aigner; Guillaume Dorothée; Klaus Armin Nave; Mikael Simons; Gabriela Constantin; Neta Rosenzweig; Alberto Pascual; Gabor C. Petzold; Jonathan Kipnis; Carmen Venegas; Marco Colonna; Jochen Walter; Andrea J. Tenner; M. Kerry O’Banion; Joern R. Steinert; Douglas L. Feinstein; Magdalena Sastre; Kiran Bhaskar; Soyon Hong; Dorothy P. Schafer; Todd Golde; Richard M. Ransohoff; David Morgan; John Breitner; Renzo Mancuso; Sean Patrick Riechers

doi:10.1038/s41577-024-01104-7

Neuroinflammation in Alzheimer disease

Michael T. Heneka, Wiesje M. van der Flier, Frank Jessen, Jeroen Hoozemanns, Dietmar Rudolf Thal, Delphine Boche, Frederic Brosseron, Charlotte Teunissen, Henrik Zetterberg, Andreas H. Jacobs, Paul Edison, Alfredo Ramirez, Carlos Cruchaga, Jean Charles Lambert, Agustin Ruiz Laza, Jose Vicente Sanchez-Mut, Andre Fischer, Sergio Castro-Gomez, Thor D. Stein, Luca KleineidamMichael Wagner, Jonas J. Neher, Colm Cunningham, Sim K. Singhrao, Marco Prinz, Christopher K. Glass, Johannes C.M. Schlachetzki, Oleg Butovsky, Kilian Kleemann, Philip L. De Jaeger, Hannah Scheiblich, Guy C. Brown, Gary Landreth, Miguel Moutinho, Jaime Grutzendler, Diego Gomez-Nicola, Róisín M. McManus, Katrin Andreasson, Christina Ising, Deniz Karabag, Darren J. Baker, Shane A. Liddelow, Alexei Verkhratsky, Malu Tansey, Alon Monsonego, Ludwig Aigner, Guillaume Dorothée, Klaus Armin Nave, Mikael Simons, Gabriela Constantin, Neta Rosenzweig, Alberto Pascual, Gabor C. Petzold, Jonathan Kipnis, Carmen Venegas, Marco Colonna, Jochen Walter, Andrea J. Tenner, M. Kerry O’Banion, Joern R. Steinert, Douglas L. Feinstein, Magdalena Sastre, Kiran Bhaskar, Soyon Hong, Dorothy P. Schafer, Todd Golde, Richard M. Ransohoff, David Morgan, John Breitner, Renzo Mancuso, Sean Patrick Riechers

The Shraga Segal Department of Microbiology and Immunology

Research output: Contribution to journal › Review article › peer-review

Abstract

Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. Here, we review the cell types and pathological mechanisms involved in disease development as well as the influence of genetics and lifestyle factors. Given the decade-long preclinical stage of Alzheimer disease, these mechanisms and their interactions are driving forces behind the spread and progression of the disease. The identification of treatment opportunities will require a precise understanding of the cells and mechanisms involved as well as a clear definition of their temporal and topographical nature. We will also discuss new therapeutic strategies for targeting neuroinflammation, which are now entering the clinic and showing promise for patients.

Original language	English
Article number	170
Journal	Nature Reviews Immunology
DOIs	https://doi.org/10.1038/s41577-024-01104-7
State	Accepted/In press - 1 Jan 2024

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/s41577-024-01104-7

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Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., Edison, P., Ramirez, A., Cruchaga, C., Lambert, J. C., Laza, A. R., Sanchez-Mut, J. V., Fischer, A., Castro-Gomez, S., Stein, T. D., ... Riechers, S. P. (Accepted/In press). Neuroinflammation in Alzheimer disease. Nature Reviews Immunology, Article 170. https://doi.org/10.1038/s41577-024-01104-7

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title = "Neuroinflammation in Alzheimer disease",

abstract = "Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. Here, we review the cell types and pathological mechanisms involved in disease development as well as the influence of genetics and lifestyle factors. Given the decade-long preclinical stage of Alzheimer disease, these mechanisms and their interactions are driving forces behind the spread and progression of the disease. The identification of treatment opportunities will require a precise understanding of the cells and mechanisms involved as well as a clear definition of their temporal and topographical nature. We will also discuss new therapeutic strategies for targeting neuroinflammation, which are now entering the clinic and showing promise for patients.",

author = "Heneka, {Michael T.} and {van der Flier}, {Wiesje M.} and Frank Jessen and Jeroen Hoozemanns and Thal, {Dietmar Rudolf} and Delphine Boche and Frederic Brosseron and Charlotte Teunissen and Henrik Zetterberg and Jacobs, {Andreas H.} and Paul Edison and Alfredo Ramirez and Carlos Cruchaga and Lambert, {Jean Charles} and Laza, {Agustin Ruiz} and Sanchez-Mut, {Jose Vicente} and Andre Fischer and Sergio Castro-Gomez and Stein, {Thor D.} and Luca Kleineidam and Michael Wagner and Neher, {Jonas J.} and Colm Cunningham and Singhrao, {Sim K.} and Marco Prinz and Glass, {Christopher K.} and Schlachetzki, {Johannes C.M.} and Oleg Butovsky and Kilian Kleemann and {De Jaeger}, {Philip L.} and Hannah Scheiblich and Brown, {Guy C.} and Gary Landreth and Miguel Moutinho and Jaime Grutzendler and Diego Gomez-Nicola and McManus, {R{\'o}is{\'i}n M.} and Katrin Andreasson and Christina Ising and Deniz Karabag and Baker, {Darren J.} and Liddelow, {Shane A.} and Alexei Verkhratsky and Malu Tansey and Alon Monsonego and Ludwig Aigner and Guillaume Doroth{\'e}e and Nave, {Klaus Armin} and Mikael Simons and Gabriela Constantin and Neta Rosenzweig and Alberto Pascual and Petzold, {Gabor C.} and Jonathan Kipnis and Carmen Venegas and Marco Colonna and Jochen Walter and Tenner, {Andrea J.} and O{\textquoteright}Banion, {M. Kerry} and Steinert, {Joern R.} and Feinstein, {Douglas L.} and Magdalena Sastre and Kiran Bhaskar and Soyon Hong and Schafer, {Dorothy P.} and Todd Golde and Ransohoff, {Richard M.} and David Morgan and John Breitner and Renzo Mancuso and Riechers, {Sean Patrick}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2024.",

year = "2024",

month = jan,

day = "1",

doi = "10.1038/s41577-024-01104-7",

language = "English",

journal = "Nature Reviews Immunology",

issn = "1474-1733",

publisher = "Nature Research",

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Heneka, MT, van der Flier, WM, Jessen, F, Hoozemanns, J, Thal, DR, Boche, D, Brosseron, F, Teunissen, C, Zetterberg, H, Jacobs, AH, Edison, P, Ramirez, A, Cruchaga, C, Lambert, JC, Laza, AR, Sanchez-Mut, JV, Fischer, A, Castro-Gomez, S, Stein, TD, Kleineidam, L, Wagner, M, Neher, JJ, Cunningham, C, Singhrao, SK, Prinz, M, Glass, CK, Schlachetzki, JCM, Butovsky, O, Kleemann, K, De Jaeger, PL, Scheiblich, H, Brown, GC, Landreth, G, Moutinho, M, Grutzendler, J, Gomez-Nicola, D, McManus, RM, Andreasson, K, Ising, C, Karabag, D, Baker, DJ, Liddelow, SA, Verkhratsky, A, Tansey, M, Monsonego, A, Aigner, L, Dorothée, G, Nave, KA, Simons, M, Constantin, G, Rosenzweig, N, Pascual, A, Petzold, GC, Kipnis, J, Venegas, C, Colonna, M, Walter, J, Tenner, AJ, O’Banion, MK, Steinert, JR, Feinstein, DL, Sastre, M, Bhaskar, K, Hong, S, Schafer, DP, Golde, T, Ransohoff, RM, Morgan, D, Breitner, J, Mancuso, R & Riechers, SP 2024, 'Neuroinflammation in Alzheimer disease', Nature Reviews Immunology. https://doi.org/10.1038/s41577-024-01104-7

TY - JOUR

T1 - Neuroinflammation in Alzheimer disease

AU - Heneka, Michael T.

AU - van der Flier, Wiesje M.

AU - Jessen, Frank

AU - Hoozemanns, Jeroen

AU - Thal, Dietmar Rudolf

AU - Boche, Delphine

AU - Brosseron, Frederic

AU - Teunissen, Charlotte

AU - Zetterberg, Henrik

AU - Jacobs, Andreas H.

AU - Edison, Paul

AU - Ramirez, Alfredo

AU - Cruchaga, Carlos

AU - Lambert, Jean Charles

AU - Laza, Agustin Ruiz

AU - Sanchez-Mut, Jose Vicente

AU - Fischer, Andre

AU - Castro-Gomez, Sergio

AU - Stein, Thor D.

AU - Kleineidam, Luca

AU - Wagner, Michael

AU - Neher, Jonas J.

AU - Cunningham, Colm

AU - Singhrao, Sim K.

AU - Prinz, Marco

AU - Glass, Christopher K.

AU - Schlachetzki, Johannes C.M.

AU - Butovsky, Oleg

AU - Kleemann, Kilian

AU - De Jaeger, Philip L.

AU - Scheiblich, Hannah

AU - Brown, Guy C.

AU - Landreth, Gary

AU - Moutinho, Miguel

AU - Grutzendler, Jaime

AU - Gomez-Nicola, Diego

AU - McManus, Róisín M.

AU - Andreasson, Katrin

AU - Ising, Christina

AU - Karabag, Deniz

AU - Baker, Darren J.

AU - Liddelow, Shane A.

AU - Verkhratsky, Alexei

AU - Tansey, Malu

AU - Monsonego, Alon

AU - Aigner, Ludwig

AU - Dorothée, Guillaume

AU - Nave, Klaus Armin

AU - Simons, Mikael

AU - Constantin, Gabriela

AU - Rosenzweig, Neta

AU - Pascual, Alberto

AU - Petzold, Gabor C.

AU - Kipnis, Jonathan

AU - Venegas, Carmen

AU - Colonna, Marco

AU - Walter, Jochen

AU - Tenner, Andrea J.

AU - O’Banion, M. Kerry

AU - Steinert, Joern R.

AU - Feinstein, Douglas L.

AU - Sastre, Magdalena

AU - Bhaskar, Kiran

AU - Hong, Soyon

AU - Schafer, Dorothy P.

AU - Golde, Todd

AU - Ransohoff, Richard M.

AU - Morgan, David

AU - Breitner, John

AU - Mancuso, Renzo

AU - Riechers, Sean Patrick

PY - 2024/1/1

Y1 - 2024/1/1

N2 - Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. Here, we review the cell types and pathological mechanisms involved in disease development as well as the influence of genetics and lifestyle factors. Given the decade-long preclinical stage of Alzheimer disease, these mechanisms and their interactions are driving forces behind the spread and progression of the disease. The identification of treatment opportunities will require a precise understanding of the cells and mechanisms involved as well as a clear definition of their temporal and topographical nature. We will also discuss new therapeutic strategies for targeting neuroinflammation, which are now entering the clinic and showing promise for patients.

AB - Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. Here, we review the cell types and pathological mechanisms involved in disease development as well as the influence of genetics and lifestyle factors. Given the decade-long preclinical stage of Alzheimer disease, these mechanisms and their interactions are driving forces behind the spread and progression of the disease. The identification of treatment opportunities will require a precise understanding of the cells and mechanisms involved as well as a clear definition of their temporal and topographical nature. We will also discuss new therapeutic strategies for targeting neuroinflammation, which are now entering the clinic and showing promise for patients.

UR - http://www.scopus.com/inward/record.url?scp=85212195367&partnerID=8YFLogxK

U2 - 10.1038/s41577-024-01104-7

DO - 10.1038/s41577-024-01104-7

M3 - Review article

C2 - 39653749

AN - SCOPUS:85212195367

SN - 1474-1733

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

M1 - 170

ER -

Neuroinflammation in Alzheimer disease

Abstract

ASJC Scopus subject areas

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