Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients

J. Biederman; R. Rimon; R. Ebstein; J. Zohar; R. Belmaker

doi:10.1159/000117563

Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients

J. Biederman, R. Rimon, R. Ebstein, J. Zohar, R. Belmaker

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Abstract

Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 wk antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.

Original language	English
Pages (from-to)	324-327
Number of pages	4
Journal	Neuropsychobiology
Volume	2
Issue number	5-6
DOIs	https://doi.org/10.1159/000117563
State	Published - 1 Jan 1977

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Psychiatry and Mental health
Biological Psychiatry

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10.1159/000117563

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title = "Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients",

abstract = "Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 wk antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.",

author = "J. Biederman and R. Rimon and R. Ebstein and J. Zohar and R. Belmaker",

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AU - Rimon, R.

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AU - Zohar, J.

AU - Belmaker, R.

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N2 - Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 wk antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.

AB - Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 wk antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.

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Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients

Abstract

ASJC Scopus subject areas

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