Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients

J. Biederman, R. Rimon, R. Ebstein, J. Zohar, R. Belmaker

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations


    Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 wk antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.

    Original languageEnglish
    Pages (from-to)324-327
    Number of pages4
    Issue number5-6
    StatePublished - 1 Jan 1977

    ASJC Scopus subject areas

    • Neuropsychology and Physiological Psychology
    • Psychiatry and Mental health
    • Biological Psychiatry


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