Neurophysiologic studies in congenital insensitivity to pain with anhidrosis

Zamir Shorer; Shimon W. Moses; Eliahu Hershkovitz; Vered Pinsk; Jacov Levy

doi:10.1016/S0887-8994(01)00347-2

Neurophysiologic studies in congenital insensitivity to pain with anhidrosis

Zamir Shorer, Shimon W. Moses, Eliahu Hershkovitz, Vered Pinsk, Jacov Levy

Basic Sciences Divisions

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33 Scopus citations

Abstract

Thirteen patients with congenital insensitivity to pain and anhidrosis, carrying a mutation at the TRK-A gene, were studied. Neurologic examination revealed vestigial pain sensitivity, suggesting an incomplete involvement of the affected nerves. All 13 patients manifested normal electrophysiologic studies but striking absence of sympathetic skin responses. We suggest the use of the sympathetic skin response test in the clinical evaluation of patients suspected of having congenital insensitivity to pain and anhidrosis.

Original language	English
Pages (from-to)	397-400
Number of pages	4
Journal	Pediatric Neurology
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/S0887-8994(01)00347-2
State	Published - 1 Dec 2001

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Neurology
Developmental Neuroscience
Clinical Neurology

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abstract = "Thirteen patients with congenital insensitivity to pain and anhidrosis, carrying a mutation at the TRK-A gene, were studied. Neurologic examination revealed vestigial pain sensitivity, suggesting an incomplete involvement of the affected nerves. All 13 patients manifested normal electrophysiologic studies but striking absence of sympathetic skin responses. We suggest the use of the sympathetic skin response test in the clinical evaluation of patients suspected of having congenital insensitivity to pain and anhidrosis.",

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AU - Levy, Jacov

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AB - Thirteen patients with congenital insensitivity to pain and anhidrosis, carrying a mutation at the TRK-A gene, were studied. Neurologic examination revealed vestigial pain sensitivity, suggesting an incomplete involvement of the affected nerves. All 13 patients manifested normal electrophysiologic studies but striking absence of sympathetic skin responses. We suggest the use of the sympathetic skin response test in the clinical evaluation of patients suspected of having congenital insensitivity to pain and anhidrosis.

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Neurophysiologic studies in congenital insensitivity to pain with anhidrosis

Abstract

ASJC Scopus subject areas

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