Neurophysiologic studies in congenital insensitivity to pain with anhidrosis

Zamir Shorer, Shimon W. Moses, Eliahu Hershkovitz, Vered Pinsk, Jacov Levy

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Thirteen patients with congenital insensitivity to pain and anhidrosis, carrying a mutation at the TRK-A gene, were studied. Neurologic examination revealed vestigial pain sensitivity, suggesting an incomplete involvement of the affected nerves. All 13 patients manifested normal electrophysiologic studies but striking absence of sympathetic skin responses. We suggest the use of the sympathetic skin response test in the clinical evaluation of patients suspected of having congenital insensitivity to pain and anhidrosis.

Original languageEnglish
Pages (from-to)397-400
Number of pages4
JournalPediatric Neurology
Issue number5
StatePublished - 1 Dec 2001

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology


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