Neurotransmitter synthesis in the nervous system of the mollusc Hermissenda

Eliahu Heldman, Daniel L. Alkon

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


1. Biochemical and histochemical analysis of the circumesophageal ganglia of the nudibranch mollusc Hermissenda crassicornis revealed four putative neurotransmitters: acetylcholine, dopamine, serotonin and histamine. 2. Acetylcholine was synthesized and accumulated within the neuropile where all known synaptic interactions occur. 3. Histochemical staining demonstrated that acetylcholinesterase is almost entirely localized in the neuropile region. 4. Degradation of ACh was increased by perfusing the preparation with seawater containing high K+. 5. Study of the enzymes involved in the metabolism of the above-mentioned neurotransmitters revealed that choline-acetyltransferase had much higher specific activity than either tyrosine or tryptophan hydroxylases. 6. The temperature optimum found for the CAT was 20°C, while tryptophan and tyrosine hydroxylase showed an increase in their activity up to 30 and 35°C respectively. 7. AChE was found to have high activity throughout the temperature range tested (0-35°C).

Original languageEnglish
Pages (from-to)117-125
Number of pages9
JournalComparative biochemistry and physiology. C: Comparative pharmacology
Issue number2
StatePublished - 1 Jan 1978
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Pharmacology


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