Neutropenia complicating Rh-hydrops fetalis: The effect of treatment with recombinant human granulocyte colony-stimulating factor (rhG-CSF)

Nirit Segal, Eugene Leibovitz, Ada Juster-Reicher, Smadar Even-Tov, Benjamin Mogilner, Yigal Barak

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Neutropenia is a less commonly encountered feature of Rh hemolytic disease of the newborn, and its management may be problematic. Two newborn infants with neutropenia complicating Rh incompatibility-induced hydrops fetalis were treated with intravenous recombinant human granulocyte colony- stimulating factor (rhG-CSF), 5 μg/kg/day for 5 days. Both patients responded to therapy with a rapid and persistent increase of their neutrophil counts to normal values. The treatment was well tolerated and no adverse clinical events were observed. rhG-CSF induces a significant increase in peripheral absolute neutrophil counts of neutropenic neonates with Rh hydrops fetalis and was well tolerated. The contribution of rhG-CSF to clinical recovery warrants further investigation.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalPediatric Hematology and Oncology
Volume15
Issue number2
DOIs
StatePublished - 1 Jan 1998
Externally publishedYes

Keywords

  • G-CSF
  • Hydrops
  • Neutropenia
  • Rh incompatibility

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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