Neutropenia complicating Rh-hydrops fetalis: The effect of treatment with recombinant human granulocyte colony-stimulating factor (rhG-CSF)

Nirit Segal; Eugene Leibovitz; Ada Juster-Reicher; Smadar Even-Tov; Benjamin Mogilner; Yigal Barak

doi:10.3109/08880019809167235

Neutropenia complicating Rh-hydrops fetalis: The effect of treatment with recombinant human granulocyte colony-stimulating factor (rhG-CSF)

Nirit Segal, Eugene Leibovitz, Ada Juster-Reicher, Smadar Even-Tov, Benjamin Mogilner, Yigal Barak

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Neutropenia is a less commonly encountered feature of Rh hemolytic disease of the newborn, and its management may be problematic. Two newborn infants with neutropenia complicating Rh incompatibility-induced hydrops fetalis were treated with intravenous recombinant human granulocyte colony- stimulating factor (rhG-CSF), 5 μg/kg/day for 5 days. Both patients responded to therapy with a rapid and persistent increase of their neutrophil counts to normal values. The treatment was well tolerated and no adverse clinical events were observed. rhG-CSF induces a significant increase in peripheral absolute neutrophil counts of neutropenic neonates with Rh hydrops fetalis and was well tolerated. The contribution of rhG-CSF to clinical recovery warrants further investigation.

Original language	English
Pages (from-to)	193-197
Number of pages	5
Journal	Pediatric Hematology and Oncology
Volume	15
Issue number	2
DOIs	https://doi.org/10.3109/08880019809167235
State	Published - 1 Jan 1998

Keywords

G-CSF
Hydrops
Neutropenia
Rh incompatibility

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.3109/08880019809167235

Cite this

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abstract = "Neutropenia is a less commonly encountered feature of Rh hemolytic disease of the newborn, and its management may be problematic. Two newborn infants with neutropenia complicating Rh incompatibility-induced hydrops fetalis were treated with intravenous recombinant human granulocyte colony- stimulating factor (rhG-CSF), 5 μg/kg/day for 5 days. Both patients responded to therapy with a rapid and persistent increase of their neutrophil counts to normal values. The treatment was well tolerated and no adverse clinical events were observed. rhG-CSF induces a significant increase in peripheral absolute neutrophil counts of neutropenic neonates with Rh hydrops fetalis and was well tolerated. The contribution of rhG-CSF to clinical recovery warrants further investigation.",

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AB - Neutropenia is a less commonly encountered feature of Rh hemolytic disease of the newborn, and its management may be problematic. Two newborn infants with neutropenia complicating Rh incompatibility-induced hydrops fetalis were treated with intravenous recombinant human granulocyte colony- stimulating factor (rhG-CSF), 5 μg/kg/day for 5 days. Both patients responded to therapy with a rapid and persistent increase of their neutrophil counts to normal values. The treatment was well tolerated and no adverse clinical events were observed. rhG-CSF induces a significant increase in peripheral absolute neutrophil counts of neutropenic neonates with Rh hydrops fetalis and was well tolerated. The contribution of rhG-CSF to clinical recovery warrants further investigation.

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Neutropenia complicating Rh-hydrops fetalis: The effect of treatment with recombinant human granulocyte colony-stimulating factor (rhG-CSF)

Abstract

Keywords

ASJC Scopus subject areas

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