Nevoid basal cell carcinoma syndrome: Report of a case with associated Hodgkin’s disease

A. Zvulunov, D. Strother, G. Zirbel, L. G. Rabinowitz, N. B. Esterly

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Purpose: Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal-dominant multisystem disorder characterized by various congenital anomalies, multiple cutaneous basal cell carcinomas (BCCs), and increased risk for other benign and malignant tumors. We report a 13-year-old girl with NBCCS who developed cutaneous BCCs 2 years after radiotherapy for Hodgkin’s lymphoma. Patients and Methods: Review of clinical and laboratory observations of patients with NBCCS suggest a close relationship between radiotherapy and the early emergence of numerous BCCs. However, in vitro studies of the effect of radiosensitivity on cells cultured from patients with NBCCS show inconsistent results. Results: Clarification of the role of radiotherapy in the induction of BCCs in NBCCS requires additional studies. Nevertheless, recognition of the syndrome is important because whenever possible radiotherapy for secondary tumors might be effectively replaced by chemotherapy.

Original languageEnglish
Pages (from-to)66-70
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Issue number1
StatePublished - 1 Jan 1995
Externally publishedYes


  • Hodgkin’s disease
  • Nevoid basal cell carcinoma syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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