New candidate virus in association with Hodgkin's disease

D. Benharroch, Y. Shemer-Avni, A. Levy, Y. Y. Myint, S. Ariad, B. Rager, M. Sacks, J. Gopas

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Epidemiologic and molecular investigations of Hodgkin's disease (HD) suggest a strong infectious association. The Epstein-Barr virus (EBV), together with its viral proteins, is expressed in Hodgkin-Reed-Sternberg (HRS) cells in the lymph nodes involved by HD. EBV is more likely to be related to childhood and older adult cases of HD and is much less frequently expressed in young adult HD patients, the group most expected to be associated with an infectious agent. In addition, the "hit and run" theory of EBV infection remains speculative and no other lymphotropic viruses studied to date seem to satisfy the quest for a new candidate virus in young adults with HD. We have recently found preliminary evidence suggesting a possible association between the measles virus (MV) and HD. This evidence is the subject of the present review.

Original languageEnglish
Pages (from-to)605-610
Number of pages6
JournalLeukemia and Lymphoma
Issue number4
StatePublished - 1 Apr 2003


  • Epstein-Barr virus
  • Hodgkin's disease
  • Measles virus
  • Young adults

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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