New candidate virus in association with Hodgkin's disease

D. Benharroch; Y. Shemer-Avni; A. Levy; Y. Y. Myint; S. Ariad; B. Rager; M. Sacks; J. Gopas

doi:10.1080/1042819021000037994

New candidate virus in association with Hodgkin's disease

D. Benharroch, Y. Shemer-Avni, A. Levy, Y. Y. Myint, S. Ariad, B. Rager, M. Sacks, J. Gopas

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Epidemiologic and molecular investigations of Hodgkin's disease (HD) suggest a strong infectious association. The Epstein-Barr virus (EBV), together with its viral proteins, is expressed in Hodgkin-Reed-Sternberg (HRS) cells in the lymph nodes involved by HD. EBV is more likely to be related to childhood and older adult cases of HD and is much less frequently expressed in young adult HD patients, the group most expected to be associated with an infectious agent. In addition, the "hit and run" theory of EBV infection remains speculative and no other lymphotropic viruses studied to date seem to satisfy the quest for a new candidate virus in young adults with HD. We have recently found preliminary evidence suggesting a possible association between the measles virus (MV) and HD. This evidence is the subject of the present review.

Original language	English
Pages (from-to)	605-610
Number of pages	6
Journal	Leukemia and Lymphoma
Volume	44
Issue number	4
DOIs	https://doi.org/10.1080/1042819021000037994
State	Published - 1 Apr 2003

Keywords

Epstein-Barr virus
Hodgkin's disease
Measles virus
Young adults

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/1042819021000037994

Cite this

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title = "New candidate virus in association with Hodgkin's disease",

abstract = "Epidemiologic and molecular investigations of Hodgkin's disease (HD) suggest a strong infectious association. The Epstein-Barr virus (EBV), together with its viral proteins, is expressed in Hodgkin-Reed-Sternberg (HRS) cells in the lymph nodes involved by HD. EBV is more likely to be related to childhood and older adult cases of HD and is much less frequently expressed in young adult HD patients, the group most expected to be associated with an infectious agent. In addition, the {"}hit and run{"} theory of EBV infection remains speculative and no other lymphotropic viruses studied to date seem to satisfy the quest for a new candidate virus in young adults with HD. We have recently found preliminary evidence suggesting a possible association between the measles virus (MV) and HD. This evidence is the subject of the present review.",

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T1 - New candidate virus in association with Hodgkin's disease

AU - Benharroch, D.

AU - Shemer-Avni, Y.

AU - Levy, A.

AU - Myint, Y. Y.

AU - Ariad, S.

AU - Rager, B.

AU - Sacks, M.

AU - Gopas, J.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Epidemiologic and molecular investigations of Hodgkin's disease (HD) suggest a strong infectious association. The Epstein-Barr virus (EBV), together with its viral proteins, is expressed in Hodgkin-Reed-Sternberg (HRS) cells in the lymph nodes involved by HD. EBV is more likely to be related to childhood and older adult cases of HD and is much less frequently expressed in young adult HD patients, the group most expected to be associated with an infectious agent. In addition, the "hit and run" theory of EBV infection remains speculative and no other lymphotropic viruses studied to date seem to satisfy the quest for a new candidate virus in young adults with HD. We have recently found preliminary evidence suggesting a possible association between the measles virus (MV) and HD. This evidence is the subject of the present review.

AB - Epidemiologic and molecular investigations of Hodgkin's disease (HD) suggest a strong infectious association. The Epstein-Barr virus (EBV), together with its viral proteins, is expressed in Hodgkin-Reed-Sternberg (HRS) cells in the lymph nodes involved by HD. EBV is more likely to be related to childhood and older adult cases of HD and is much less frequently expressed in young adult HD patients, the group most expected to be associated with an infectious agent. In addition, the "hit and run" theory of EBV infection remains speculative and no other lymphotropic viruses studied to date seem to satisfy the quest for a new candidate virus in young adults with HD. We have recently found preliminary evidence suggesting a possible association between the measles virus (MV) and HD. This evidence is the subject of the present review.

KW - Epstein-Barr virus

KW - Hodgkin's disease

KW - Measles virus

KW - Young adults

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SN - 1042-8194

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JO - Leukemia and Lymphoma

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New candidate virus in association with Hodgkin's disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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