New insights into the structural organization of eukaryotic and prokaryotic cytoskeletons using cryo-electron tomography

Julia Kürner, Ohad Medalia, Alexandros A. Linaroudis, Wolfgang Baumeister

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Cryo-electron tomography (cryo-ET) is an emerging imaging technology that combines the potential of three-dimensional (3-D) imaging at molecular resolution (<5 nm) with a close-to-life preservation of the specimen. In conjunction with pattern recognition techniques, it enables us to map the molecular landscape inside cells. The application of cryo-ET to intact cells provides novel insights into the structure and the spatial organization of the cytoskeleton in prokaryotic and eukaryotic cells.

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalExperimental Cell Research
Volume301
Issue number1
DOIs
StatePublished - 15 Nov 2004
Externally publishedYes

Keywords

  • Actin
  • Electron microscopy
  • Macromolecular structure
  • Motility
  • Spiroplasma

ASJC Scopus subject areas

  • Cell Biology

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