New MCR based on intramolecular Heck reaction under aerobic conditions: A direct access to cytotoxic fused N-heterocycles

Raju Adepu, Bagineni Prasad, Mohd Ashraf Ashfaq, Nasreen Z. Ehtesham, Manojit Pal

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We report a new MCR involving the reaction of isatoic anhydrides, allyl amine and o-bromo arylaldehydes in the presence of Pd(OAc)2, X-Phos and air to afford various isoquinolino[1,2-b]quinazolinones as new cytotoxic agents. The strategy was extended successfully towards the synthesis of a methyl analogue of 7,8-dehydrorutaecarpine.

Original languageEnglish
Pages (from-to)49324-49328
Number of pages5
JournalRSC Advances
Volume4
Issue number90
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

Fingerprint

Dive into the research topics of 'New MCR based on intramolecular Heck reaction under aerobic conditions: A direct access to cytotoxic fused N-heterocycles'. Together they form a unique fingerprint.

Cite this