New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review

Iftach Sagy; Lior Zeller; Yael Raviv; Tzvika Porges; Amir Bieber; Mahmoud Abu-Shakra

doi:10.1007/s00296-022-05203-3

New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review

Iftach Sagy, Lior Zeller, Yael Raviv, Tzvika Porges, Amir Bieber, Mahmoud Abu-Shakra

Medical School for International Health

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Emerging data evaluated the possible link between the Coronavirus 19 (COVID-19) vaccine and acute flares of rheumatic autoimmune diseases. However, the association between the COVID-19 vaccine and the development of de-novo rheumatic autoimmune diseases remained unclear. We report the first case series of three male patients who developed new-onset systemic lupus erythematosus following receiving Pfizer BNT162b2 mRNA vaccination. The clinical characteristics share some similarities with drug-induced lupus. More patients with SLE following COVID-19 may be diagnosed in the future. Additional studies will provide more significant insights into the possible immunogenic influence of the COVID-19 vaccine.

Original language	English
Pages (from-to)	2261-2266
Number of pages	6
Journal	Rheumatology International
Volume	42
Issue number	12
DOIs	https://doi.org/10.1007/s00296-022-05203-3
State	Published - 1 Dec 2022

Keywords

COVID-19
Systemic lupus erythematosus
Vaccine

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology

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10.1007/s00296-022-05203-3

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title = "New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review",

abstract = "Emerging data evaluated the possible link between the Coronavirus 19 (COVID-19) vaccine and acute flares of rheumatic autoimmune diseases. However, the association between the COVID-19 vaccine and the development of de-novo rheumatic autoimmune diseases remained unclear. We report the first case series of three male patients who developed new-onset systemic lupus erythematosus following receiving Pfizer BNT162b2 mRNA vaccination. The clinical characteristics share some similarities with drug-induced lupus. More patients with SLE following COVID-19 may be diagnosed in the future. Additional studies will provide more significant insights into the possible immunogenic influence of the COVID-19 vaccine.",

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AU - Porges, Tzvika

AU - Bieber, Amir

AU - Abu-Shakra, Mahmoud

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AB - Emerging data evaluated the possible link between the Coronavirus 19 (COVID-19) vaccine and acute flares of rheumatic autoimmune diseases. However, the association between the COVID-19 vaccine and the development of de-novo rheumatic autoimmune diseases remained unclear. We report the first case series of three male patients who developed new-onset systemic lupus erythematosus following receiving Pfizer BNT162b2 mRNA vaccination. The clinical characteristics share some similarities with drug-induced lupus. More patients with SLE following COVID-19 may be diagnosed in the future. Additional studies will provide more significant insights into the possible immunogenic influence of the COVID-19 vaccine.

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New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review

Abstract

Keywords

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