New technology for diagnosis of bacterial vaginosis

Walter Chaim, Zeev Karpas, Avi Lorber

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Objective: To replace clinical diagnosis of bacterial vaginosis (BV) with a new and rapid analytical method based on ion mobility spectrometry (IMS). IMS is an instrumental technique for identifying compounds and determining their concentrations, based on measurement of the velocity of ions drifting through air at atmospheric pressure under the influence of an electric field. The technique is particularly sensitive to amines taking less than 2min. Study design: Clinical examination of 174 samples determined 22 BV-positive and 152 BV-negative samples. IMS analyzed and recorded biogenic amine emanation mobility spectra of the 174 samples of vaginal discharge from duplicate swabs. Results: IMS confirmed 21 (true positive BV) samples with 1 false negative (21/22, sensitivity=95.5%). Out of 152 samples, 150 were confirmed true BV-negative with 2 false positive samples (specificity=98.7%), PPV: 91.3%, NPV: 100%. Conclusions: The diagnostic procedure shows high accuracy and is technically simple and rapid. The trimethylamine level becomes an index of severity of the infection.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume111
Issue number1
DOIs
StatePublished - 10 Nov 2003
Externally publishedYes

Keywords

  • Bacterial vaginosis
  • Cadaverine
  • Ion mobility spectrometry
  • Putrescine
  • Trimethylamine

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint

Dive into the research topics of 'New technology for diagnosis of bacterial vaginosis'. Together they form a unique fingerprint.

Cite this