New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice

Amnon Sintov, Sima Serafimovich, Amos Gilhar

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The purpose of this study was to test the ability of topical formulations of finasteride and flutamide to re-enlarge hair follicles in male-pattern baldness. This was evaluated by an experimental model of human scalp skin graft transplanted onto SCID mice. A comparison was made between formulations containing finasteride and flutamide, and a vehicle formulation in terms of the mean hairs per graft, length, diameter of the shafts, and structures of the growth stages of the hair. Flutamide and finasteride had a significantly higher effect (P<0.05) than the placebo in all the tested parameters, but flutamide demonstrated more hair per graft and longer hair shafts than finasteride (P<0.05). The number of hairs per graft for flutamide and finasteride groups were 1.22±0.47 and 0.88±0.95 hairs/0.5 mm2 graft, respectively, versus 0.35±0.6 hairs/graft for vehicle-treated graft. Similarly, hair lengths for flutamide and finasteride were 5.82±0.50 and 4.50±0.32 mm, respectively, versus 2.83±0.18 mm for the vehicle-treated grafts. An in vitro diffusion study of flutamide gel using hairless mouse skin demonstrated the beneficial effect of the vehicle composition in comparison with a hydroalcoholic solution or a gel containing no penetration enhancer. It is therefore suggested that this topical composition containing flutamide or finasteride may effectively result in regression of male-pattern baldness.

Original languageEnglish
Pages (from-to)125-134
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume194
Issue number1
DOIs
StatePublished - 20 Jan 2000

Keywords

  • Androgenetic alopecia
  • Finasteride
  • Flutamide
  • Mice
  • Skin permeation
  • Topical drug delivery

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