Newly synthesized bolaamphiphiles from castor oil and their aggregated morphologies for potential use in drug delivery

Monique B. Ewonkem, Sarina Grinberg, Gabriel Lemcoff, Eleonora Shaubi, Charles Linder, Eliahu Heldman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The present study focused on synthesizing bolaamphiphiles from the readily available and inexpensive castor oil, a vegetable oil, which contains about 90% of ricinoleic acid. Two classes of symmetric and asymmetric bolaamphiphiles with acetylcholine head groups were synthesized and characterized by spectroscopic analysis. These novel bolaamphiphilic compounds self-assemble in aqueous media to form stable cationic spherical nano-sized vesicles that are potential drug delivery systems.

Original languageEnglish
Pages (from-to)8557-8571
Number of pages15
JournalTetrahedron
Volume71
Issue number45
DOIs
StatePublished - 11 Nov 2015

Keywords

  • Acetylcholine
  • Bolaamphiphiles
  • Drug delivery
  • Ricinoleic acid
  • Vesicles

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