Newly synthesized bolaamphiphiles from castor oil and their aggregated morphologies for potential use in drug delivery

Monique B. Ewonkem; Sarina Grinberg; Gabriel Lemcoff; Eleonora Shaubi; Charles Linder; Eliahu Heldman

doi:10.1016/j.tet.2015.09.031

Newly synthesized bolaamphiphiles from castor oil and their aggregated morphologies for potential use in drug delivery

Monique B. Ewonkem, Sarina Grinberg, Gabriel Lemcoff, Eleonora Shaubi, Charles Linder, Eliahu Heldman

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The present study focused on synthesizing bolaamphiphiles from the readily available and inexpensive castor oil, a vegetable oil, which contains about 90% of ricinoleic acid. Two classes of symmetric and asymmetric bolaamphiphiles with acetylcholine head groups were synthesized and characterized by spectroscopic analysis. These novel bolaamphiphilic compounds self-assemble in aqueous media to form stable cationic spherical nano-sized vesicles that are potential drug delivery systems.

Original language	English
Pages (from-to)	8557-8571
Number of pages	15
Journal	Tetrahedron
Volume	71
Issue number	45
DOIs	https://doi.org/10.1016/j.tet.2015.09.031
State	Published - 11 Nov 2015

Keywords

Acetylcholine
Bolaamphiphiles
Drug delivery
Ricinoleic acid
Vesicles

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2015.09.031

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title = "Newly synthesized bolaamphiphiles from castor oil and their aggregated morphologies for potential use in drug delivery",

abstract = "The present study focused on synthesizing bolaamphiphiles from the readily available and inexpensive castor oil, a vegetable oil, which contains about 90\% of ricinoleic acid. Two classes of symmetric and asymmetric bolaamphiphiles with acetylcholine head groups were synthesized and characterized by spectroscopic analysis. These novel bolaamphiphilic compounds self-assemble in aqueous media to form stable cationic spherical nano-sized vesicles that are potential drug delivery systems.",

keywords = "Acetylcholine, Bolaamphiphiles, Drug delivery, Ricinoleic acid, Vesicles",

author = "Ewonkem, \{Monique B.\} and Sarina Grinberg and Gabriel Lemcoff and Eleonora Shaubi and Charles Linder and Eliahu Heldman",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd",

year = "2015",

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doi = "10.1016/j.tet.2015.09.031",

language = "English",

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T1 - Newly synthesized bolaamphiphiles from castor oil and their aggregated morphologies for potential use in drug delivery

AU - Ewonkem, Monique B.

AU - Grinberg, Sarina

AU - Lemcoff, Gabriel

AU - Shaubi, Eleonora

AU - Linder, Charles

AU - Heldman, Eliahu

PY - 2015/11/11

Y1 - 2015/11/11

N2 - The present study focused on synthesizing bolaamphiphiles from the readily available and inexpensive castor oil, a vegetable oil, which contains about 90% of ricinoleic acid. Two classes of symmetric and asymmetric bolaamphiphiles with acetylcholine head groups were synthesized and characterized by spectroscopic analysis. These novel bolaamphiphilic compounds self-assemble in aqueous media to form stable cationic spherical nano-sized vesicles that are potential drug delivery systems.

AB - The present study focused on synthesizing bolaamphiphiles from the readily available and inexpensive castor oil, a vegetable oil, which contains about 90% of ricinoleic acid. Two classes of symmetric and asymmetric bolaamphiphiles with acetylcholine head groups were synthesized and characterized by spectroscopic analysis. These novel bolaamphiphilic compounds self-assemble in aqueous media to form stable cationic spherical nano-sized vesicles that are potential drug delivery systems.

KW - Acetylcholine

KW - Bolaamphiphiles

KW - Drug delivery

KW - Ricinoleic acid

KW - Vesicles

UR - https://www.scopus.com/pages/publications/85041681353

U2 - 10.1016/j.tet.2015.09.031

DO - 10.1016/j.tet.2015.09.031

M3 - Article

AN - SCOPUS:85041681353

SN - 0040-4020

VL - 71

SP - 8557

EP - 8571

JO - Tetrahedron

JF - Tetrahedron

IS - 45

ER -

Newly synthesized bolaamphiphiles from castor oil and their aggregated morphologies for potential use in drug delivery

Abstract

Keywords

ASJC Scopus subject areas

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