Nimesulide prevents lipopolysaccharide-induced elevation in plasma tumor necrosis factor-α in rats

Abed Azab; Vadim Fraifeld; Jacob Kaplanski

doi:10.1016/s0024-3205(99)80011-3

Nimesulide prevents lipopolysaccharide-induced elevation in plasma tumor necrosis factor-α in rats

Abed Azab, Vadim Fraifeld, Jacob Kaplanski

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The present study was undertaken to test the hypothesis of possible inhibitory effect of nimesulide (4-nitro-2-phenoxymethane-sulfoxide) on plasma TNF-α level. Male Sprague-Dawley rots were injected intraperitoneally (ip) with E. coli lipopolysaccharide (LPS; 1 mg/kg), which resulted in a dramatic increase in plasma TNF-α level peaked 60 min post injection (3890 ± 280 pg/ml, compared to undetectable values in the control group). Nimesulide (30 mg/kg) injected ip 60 min prior to LPS, prevented LPS-induced elevation in plasma TNF-α. Nimesulide alone did not alter circulating levels of TNF-α. It appears that the anti-inflammatory properties of nimesulide may in part be attributed to its inhibitory effect on TNF-α production.

Original language	English
Pages (from-to)	323-327
Number of pages	5
Journal	Life Sciences
Volume	63
Issue number	23
DOIs	https://doi.org/10.1016/s0024-3205(99)80011-3
State	Published - 30 Oct 1998

Keywords

Lipopolysaccharide
Nimesulide
Rat
TNF-α

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

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10.1016/s0024-3205(99)80011-3

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title = "Nimesulide prevents lipopolysaccharide-induced elevation in plasma tumor necrosis factor-α in rats",

abstract = "The present study was undertaken to test the hypothesis of possible inhibitory effect of nimesulide (4-nitro-2-phenoxymethane-sulfoxide) on plasma TNF-α level. Male Sprague-Dawley rots were injected intraperitoneally (ip) with E. coli lipopolysaccharide (LPS; 1 mg/kg), which resulted in a dramatic increase in plasma TNF-α level peaked 60 min post injection (3890 ± 280 pg/ml, compared to undetectable values in the control group). Nimesulide (30 mg/kg) injected ip 60 min prior to LPS, prevented LPS-induced elevation in plasma TNF-α. Nimesulide alone did not alter circulating levels of TNF-α. It appears that the anti-inflammatory properties of nimesulide may in part be attributed to its inhibitory effect on TNF-α production.",

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T1 - Nimesulide prevents lipopolysaccharide-induced elevation in plasma tumor necrosis factor-α in rats

AU - Azab, Abed

AU - Fraifeld, Vadim

AU - Kaplanski, Jacob

PY - 1998/10/30

Y1 - 1998/10/30

N2 - The present study was undertaken to test the hypothesis of possible inhibitory effect of nimesulide (4-nitro-2-phenoxymethane-sulfoxide) on plasma TNF-α level. Male Sprague-Dawley rots were injected intraperitoneally (ip) with E. coli lipopolysaccharide (LPS; 1 mg/kg), which resulted in a dramatic increase in plasma TNF-α level peaked 60 min post injection (3890 ± 280 pg/ml, compared to undetectable values in the control group). Nimesulide (30 mg/kg) injected ip 60 min prior to LPS, prevented LPS-induced elevation in plasma TNF-α. Nimesulide alone did not alter circulating levels of TNF-α. It appears that the anti-inflammatory properties of nimesulide may in part be attributed to its inhibitory effect on TNF-α production.

AB - The present study was undertaken to test the hypothesis of possible inhibitory effect of nimesulide (4-nitro-2-phenoxymethane-sulfoxide) on plasma TNF-α level. Male Sprague-Dawley rots were injected intraperitoneally (ip) with E. coli lipopolysaccharide (LPS; 1 mg/kg), which resulted in a dramatic increase in plasma TNF-α level peaked 60 min post injection (3890 ± 280 pg/ml, compared to undetectable values in the control group). Nimesulide (30 mg/kg) injected ip 60 min prior to LPS, prevented LPS-induced elevation in plasma TNF-α. Nimesulide alone did not alter circulating levels of TNF-α. It appears that the anti-inflammatory properties of nimesulide may in part be attributed to its inhibitory effect on TNF-α production.

KW - Lipopolysaccharide

KW - Nimesulide

KW - Rat

KW - TNF-α

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U2 - 10.1016/s0024-3205(99)80011-3

DO - 10.1016/s0024-3205(99)80011-3

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JO - Life Sciences

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ER -

Nimesulide prevents lipopolysaccharide-induced elevation in plasma tumor necrosis factor-α in rats

Abstract

Keywords

ASJC Scopus subject areas

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