Nitric oxide and interlukin-6 levels in intellectual disability adults with epilepsy

Eli Carmeli, Reut Beiker, Mohammed Morad

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process. The role of NO and IL-6 in the neuropathogenesis of brain seizures is still questionable. In order to evaluate the role of NO and IL-6 in neurological disorders such as seizures, we investigated 19 adults with intellectual disability (ID) who suffer from epilepsy and treated for convulsions. NO metabolites (NOx) and IL-6 levels in serum obtained after night-sleep were significantly high among ID individuals diagnosed with epilepsy versus ID people without epilepsy. These results indicated that NOx and IL-6 may have a pathophysiological role in convulsions. Consequently, we suggest that professionals consider chemical inhibitors that might be helpful against the function of NO and IL-6.

Original languageEnglish
Pages (from-to)567-571
Number of pages5
JournalResearch in Developmental Disabilities
Volume30
Issue number3
DOIs
StatePublished - 1 May 2009

Keywords

  • Convulsion
  • Epilepsy
  • IL-6
  • Intellectual disability
  • Nitric oxide

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology

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