Nitrogen Dioxide pollution and hazardous household environment: What impacts more congenital malformations

D. Landau; L. Novack; M. Yitshak-Sade; B. Sarov; I. Kloog; R. Hershkovitz; I. Grotto; I. Karakis

doi:10.1016/j.chemosphere.2015.06.091

Nitrogen Dioxide pollution and hazardous household environment: What impacts more congenital malformations

D. Landau, L. Novack, M. Yitshak-Sade, B. Sarov, I. Kloog, R. Hershkovitz, I. Grotto, I. Karakis

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Nitrogen Dioxide (NO₂) is a product of fuel combustion originating mainly from industry and transportation. Studies suggest an association between NO₂ and congenital malformations (CM). We investigated an independent effect of NO₂ on CM by adjusting to individual factors and household environment in 1024 Bedouin-Arab pregnant women in southern Israel. This population is characterised by high rates of CMs, frequent consanguineous marriages, paternal smoking, temporary housing and usage of open fire for heat cooking.Information on household risk factors was collected during an interview. Ambient measurements of 24-h average NO₂ and meteorological conditions were obtained from 13 local monitors.Median value of daily NO₂ measured in the area was 6.78ppb. CM was diagnosed in 8.0% (82) of offspring. Maternal NO₂ exposure during the 1st trimester >8.6ppb was significantly associated with minor CM (RR=2.68, p=0.029). Major CM were independently associated with maternal juvenile diabetes (RR=9.97, p-value=0.002) and heating by open fire (RR=2.00, p-value=0.049), but not NO₂ exposure.We found that NO₂ emissions had an independent impact only on minor malformations, whereas major malformations depended mostly on the household environment. Antepartum deaths were associated by maternal morbidity.

Original language	English
Pages (from-to)	340-348
Number of pages	9
Journal	Chemosphere
Volume	139
DOIs	https://doi.org/10.1016/j.chemosphere.2015.06.091
State	Published - 1 Nov 2015

Keywords

Congenital malformations
Household environment
Nitrogen Dioxide
Socio-economic status

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
General Chemistry
Pollution
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.chemosphere.2015.06.091

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title = "Nitrogen Dioxide pollution and hazardous household environment: What impacts more congenital malformations",

abstract = "Nitrogen Dioxide (NO2) is a product of fuel combustion originating mainly from industry and transportation. Studies suggest an association between NO2 and congenital malformations (CM). We investigated an independent effect of NO2 on CM by adjusting to individual factors and household environment in 1024 Bedouin-Arab pregnant women in southern Israel. This population is characterised by high rates of CMs, frequent consanguineous marriages, paternal smoking, temporary housing and usage of open fire for heat cooking.Information on household risk factors was collected during an interview. Ambient measurements of 24-h average NO2 and meteorological conditions were obtained from 13 local monitors.Median value of daily NO2 measured in the area was 6.78ppb. CM was diagnosed in 8.0% (82) of offspring. Maternal NO2 exposure during the 1st trimester >8.6ppb was significantly associated with minor CM (RR=2.68, p=0.029). Major CM were independently associated with maternal juvenile diabetes (RR=9.97, p-value=0.002) and heating by open fire (RR=2.00, p-value=0.049), but not NO2 exposure.We found that NO2 emissions had an independent impact only on minor malformations, whereas major malformations depended mostly on the household environment. Antepartum deaths were associated by maternal morbidity.",

keywords = "Congenital malformations, Household environment, Nitrogen Dioxide, Socio-economic status",

author = "D. Landau and L. Novack and M. Yitshak-Sade and B. Sarov and I. Kloog and R. Hershkovitz and I. Grotto and I. Karakis",

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AU - Landau, D.

AU - Novack, L.

AU - Yitshak-Sade, M.

AU - Sarov, B.

AU - Kloog, I.

AU - Hershkovitz, R.

AU - Grotto, I.

AU - Karakis, I.

PY - 2015/11/1

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N2 - Nitrogen Dioxide (NO2) is a product of fuel combustion originating mainly from industry and transportation. Studies suggest an association between NO2 and congenital malformations (CM). We investigated an independent effect of NO2 on CM by adjusting to individual factors and household environment in 1024 Bedouin-Arab pregnant women in southern Israel. This population is characterised by high rates of CMs, frequent consanguineous marriages, paternal smoking, temporary housing and usage of open fire for heat cooking.Information on household risk factors was collected during an interview. Ambient measurements of 24-h average NO2 and meteorological conditions were obtained from 13 local monitors.Median value of daily NO2 measured in the area was 6.78ppb. CM was diagnosed in 8.0% (82) of offspring. Maternal NO2 exposure during the 1st trimester >8.6ppb was significantly associated with minor CM (RR=2.68, p=0.029). Major CM were independently associated with maternal juvenile diabetes (RR=9.97, p-value=0.002) and heating by open fire (RR=2.00, p-value=0.049), but not NO2 exposure.We found that NO2 emissions had an independent impact only on minor malformations, whereas major malformations depended mostly on the household environment. Antepartum deaths were associated by maternal morbidity.

AB - Nitrogen Dioxide (NO2) is a product of fuel combustion originating mainly from industry and transportation. Studies suggest an association between NO2 and congenital malformations (CM). We investigated an independent effect of NO2 on CM by adjusting to individual factors and household environment in 1024 Bedouin-Arab pregnant women in southern Israel. This population is characterised by high rates of CMs, frequent consanguineous marriages, paternal smoking, temporary housing and usage of open fire for heat cooking.Information on household risk factors was collected during an interview. Ambient measurements of 24-h average NO2 and meteorological conditions were obtained from 13 local monitors.Median value of daily NO2 measured in the area was 6.78ppb. CM was diagnosed in 8.0% (82) of offspring. Maternal NO2 exposure during the 1st trimester >8.6ppb was significantly associated with minor CM (RR=2.68, p=0.029). Major CM were independently associated with maternal juvenile diabetes (RR=9.97, p-value=0.002) and heating by open fire (RR=2.00, p-value=0.049), but not NO2 exposure.We found that NO2 emissions had an independent impact only on minor malformations, whereas major malformations depended mostly on the household environment. Antepartum deaths were associated by maternal morbidity.

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KW - Household environment

KW - Nitrogen Dioxide

KW - Socio-economic status

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Nitrogen Dioxide pollution and hazardous household environment: What impacts more congenital malformations

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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