TY - JOUR
T1 - NKp46
AU - Mandelboim, Ofer
AU - Porgador, Angel
N1 - Funding Information:
O.M. and A.P. are supported by research grants from the Israel Cancer Research Foundation and USA–Israel Binational Science Foundation. O.M. is also supported by research grants from the Israel Science Foundation, The Charles H. Revson Foundation (No. 153/00) and from the joint German–Israeli Research programs.
PY - 2001/10/25
Y1 - 2001/10/25
N2 - Combating diseases such as cancer and virus infection is one of the major goals of the next millennium. Remarkably, our immune system has developed a unique cell type called Natural Killer (NK) cells, able to kill cancer and virus-infected cells. The nature of the lysis/killer receptors expressed on NK cells, mediating this killing, and their ligands, is only little understood. Four lysis receptors for human NK cells were recently identified, including the NKp30, NKp44, NKp46 and CD16, all of which are capable of mediating direct killing of virus-infected and tumor cells. Among these, the NKp46 receptor is considered to be the major lysis receptor for NK cells. The viral hemagglutinin protein was recently identified as the ligand for the NKp46 receptor. However, the cellular (non-viral) ligands recognized by all of the lysis receptors (NKp30, NKp44, NKp46 and CD16) are currently unknown.
AB - Combating diseases such as cancer and virus infection is one of the major goals of the next millennium. Remarkably, our immune system has developed a unique cell type called Natural Killer (NK) cells, able to kill cancer and virus-infected cells. The nature of the lysis/killer receptors expressed on NK cells, mediating this killing, and their ligands, is only little understood. Four lysis receptors for human NK cells were recently identified, including the NKp30, NKp44, NKp46 and CD16, all of which are capable of mediating direct killing of virus-infected and tumor cells. Among these, the NKp46 receptor is considered to be the major lysis receptor for NK cells. The viral hemagglutinin protein was recently identified as the ligand for the NKp46 receptor. However, the cellular (non-viral) ligands recognized by all of the lysis receptors (NKp30, NKp44, NKp46 and CD16) are currently unknown.
KW - Lysis
KW - NK cells
KW - NKp46
UR - http://www.scopus.com/inward/record.url?scp=0034793902&partnerID=8YFLogxK
U2 - 10.1016/S1357-2725(01)00078-4
DO - 10.1016/S1357-2725(01)00078-4
M3 - Article
AN - SCOPUS:0034793902
SN - 1357-2725
VL - 33
SP - 1147
EP - 1150
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 12
ER -
