NMR-fragment based virtual screening: A brief overview

Meenakshi Singh, Benjamin Tam, Barak Akabayov

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Fragment-based drug discovery (FBDD) using NMR has become a central approach over the last twenty years for development of small molecule inhibitors against biological macromolecules, to control a variety of cellular processes. Yet, several considerations should be taken into account for obtaining a therapeutically relevant agent. In this review, we aim to list the considerations that make NMR fragment screening a successful process for yielding potent inhibitors. Factors that may govern the competence of NMR in fragment based drug discovery are discussed, as well as later steps that involve optimization of hits obtained by NMR-FBDD.

Original languageEnglish
Article number233
Issue number2
StatePublished - 1 Jan 2018


  • Fragment based virtual screening
  • Fragment-based drug discovery
  • Nuclearmagnetic resonance

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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