NMR studies on conformational and N‐configurational interconversion in 3‐methyl derivatives of the non‐narcotic analgesic drug nefopam

Keyphrases

• Opioid Analgesics 100%
• Interconversion 100%
• NMR Studies 100%
• Epimer 100%
• Analgesic Drugs 100%
• Kinetic Regime 100%
• Nefopam 100%
• Ring Conformation 100%
• Proton 50%
• 13C NMR Spectroscopy 50%
• Quaternary Ammonium Salt 50%
• Conformational Change 50%
• Hydrochloride 50%
• 1H NMR Spectroscopy 50%
• Quantitative Estimation 50%
• Major Species 50%
• Ring Inversion 50%
• Fast Exchange 50%
• Site Exchange 50%
• Slow Exchange 50%
• Conformational Equilibrium 50%
• Prototropic 50%
• Hydrochloride Salt 50%
• Vicinal Coupling Constants 50%
• Minor Species 50%
• Stereogenic 50%
• C3-epimer 50%
• Exchange Broadening 50%
• Nefopam Hydrochloride 50%
• Vicinal Couplings 50%

Chemistry

• NMR Spectroscopy 100%
• Epimer 100%
• Nefopam 100%
• Antalgic Agent 100%
• Diastereomer 66%
• Metabolite 33%
• 1H NMR Spectroscopy 33%
• Ring Inversion 33%
• 13C NMR Spectroscopy 33%
• Quaternary Ammonium Salt 33%
• Nefopam Hydrochloride 33%