N,N‐Dichlorourethane—A Selective Chlorination Reagent; Synthesis of Corticoids

Yehuda Mazur; Zvi Cohen

doi:10.1002/anie.197802811

N,N‐Dichlorourethane—A Selective Chlorination Reagent; Synthesis of Corticoids

Yehuda Mazur, Zvi Cohen

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Abstract

Introduction of a double bond between C‐9 and C‐11 of the steroid skeleton can be accomplished by (i) chlorination of the saturated steroid with N, N‐dichlorourethane (EtOCONCl₂) followed by (ii) dehydrochlorination with AgClO₄. The products, e.g.(1), can easily be functionalized at C‐11. (Figure Presented.)

Original language	English
Pages (from-to)	281-282
Number of pages	2
Journal	Angewandte Chemie - International Edition
Volume	17
Issue number	4
DOIs	https://doi.org/10.1002/anie.197802811
State	Published - 1 Jan 1978
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry

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title = "N,N‐Dichlorourethane—A Selective Chlorination Reagent; Synthesis of Corticoids",

abstract = "Introduction of a double bond between C‐9 and C‐11 of the steroid skeleton can be accomplished by (i) chlorination of the saturated steroid with N, N‐dichlorourethane (EtOCONCl2) followed by (ii) dehydrochlorination with AgClO4. The products, e.g.(1), can easily be functionalized at C‐11. (Figure Presented.)",

author = "Yehuda Mazur and Zvi Cohen",

year = "1978",

month = jan,

day = "1",

doi = "10.1002/anie.197802811",

language = "English",

volume = "17",

pages = "281--282",

journal = "Angewandte Chemie - International Edition",

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publisher = "John Wiley and Sons Ltd",

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T1 - N,N‐Dichlorourethane—A Selective Chlorination Reagent; Synthesis of Corticoids

AU - Mazur, Yehuda

AU - Cohen, Zvi

PY - 1978/1/1

Y1 - 1978/1/1

N2 - Introduction of a double bond between C‐9 and C‐11 of the steroid skeleton can be accomplished by (i) chlorination of the saturated steroid with N, N‐dichlorourethane (EtOCONCl2) followed by (ii) dehydrochlorination with AgClO4. The products, e.g.(1), can easily be functionalized at C‐11. (Figure Presented.)

AB - Introduction of a double bond between C‐9 and C‐11 of the steroid skeleton can be accomplished by (i) chlorination of the saturated steroid with N, N‐dichlorourethane (EtOCONCl2) followed by (ii) dehydrochlorination with AgClO4. The products, e.g.(1), can easily be functionalized at C‐11. (Figure Presented.)

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DO - 10.1002/anie.197802811

M3 - Article

AN - SCOPUS:84985545847

SN - 0570-0833

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JF - Angewandte Chemie - International Edition

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ER -

N,N‐Dichlorourethane—A Selective Chlorination Reagent; Synthesis of Corticoids

Abstract

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