No correlation between prolactin levels and clinical activity in patients with systemic lupus erythematosus

Dan Buskila, Margalit Lorber, Lily Neumann, Daniel Flusser, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

Objective. To assess the frequency of hyperprolactinemia and its possible clinical significance in patients with systemic lupus erythematosus (SLE). Methods. Concentrations of prolactin (PRL) were determined in 63 consecutive patients with SLE by an immunoradiometric assay. Antinuclear antibodies, anti-DNA, ribonucleoprotein, Sm, Ro, La, and anticardiolipin antibodies were determined by standard techniques. PRL concentrations were correlated with SLE clinical and serological activity. Results. Elevated serum concentrations of PRL (> 20 ng/ml) were found in 10 of 63 (15.9%) patients [21 to 57 ng/ml, mean (SD) 35.6 (13.4)]. No direct correlation between PRL levels and clinical disease activity of SLE was found (Pearson correlation r = -0.186, NS). In addition, hyperprolactinemia was not associated with serological activity. Conclusion. Mild hyperprolactinemia is present in a subset of patients with SLE but its clinical significance is still uncertain.

Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalJournal of Rheumatology
Volume23
Issue number4
StatePublished - 24 Apr 1996

Keywords

  • Autoantibodies
  • Bromocriptine
  • Disease activity
  • Hyperprolactinemia
  • Prolactin
  • SLE

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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