No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis

Roland Ivo; Thomas G. Schulze; Johannes Schumacher; Kristina Kesper; Daniel J. Müller; Ilana Kremer; Michael Dobrusin; Mustafa Mujaheed; Ibrahim Murad; Monika Blanaru; Isaam Bannoura; Alon Reshef; Rachel Bachner-Melman; Richard P. Ebstein; Peter Propping; Robert H. Belmaker; Wolfgang Maier; Marcella Rietschel; Markus M. Nöthen; Sven Cichon

doi:10.1097/01.ypg.0000218619.50386.7c

No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis

Roland Ivo, Thomas G. Schulze, Johannes Schumacher, Kristina Kesper, Daniel J. Müller, Ilana Kremer, Michael Dobrusin, Mustafa Mujaheed, Ibrahim Murad, Monika Blanaru, Isaam Bannoura, Alon Reshef, Rachel Bachner-Melman, Richard P. Ebstein, Peter Propping, Robert H. Belmaker, Wolfgang Maier, Marcella Rietschel, Markus M. Nöthen, Sven Cichon

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

OBJECTIVES: An analysis of 80 British parent-offspring trios by Wei and Hemmings in 2000 revealed thre1e out of five markers within the NOTCH4 locus to be strongly associated with schizophrenia. In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin. METHODS: Our study population comprised a German case-control sample (n=512 schizophrenia patients and n=232 controls) and two independent parent-offspring trio samples of German (n=159 trios) and Palestinian-Arab (n=208 trios) descent. We examined a total of ten single nucleotide polymorphisms within the NOTCH4 locus and the adjacent loci, spanning a region of approximately 100 kb. RESULTS: Neither single marker nor haplotype analyses showed association with schizophrenia. In addition, analyses of the German case-control and trio samples revealed no significant association between NOTCH4 polymorphisms and early-onset schizophrenia. CONCLUSIONS: Our results suggest that NOTCH4 is unlikely to play a major role in the genetic predisposition to schizophrenia in the German or the Palestinian-Arab population.

Original language	English
Pages (from-to)	197-203
Number of pages	7
Journal	Psychiatric Genetics
Volume	16
Issue number	5
DOIs	https://doi.org/10.1097/01.ypg.0000218619.50386.7c
State	Published - 1 Oct 2006
Externally published	Yes

Keywords

Age of onset
Association analysis
NOTCH4
Schizophrenia
Single nucleotide polymorphism

ASJC Scopus subject areas

Genetics
Genetics(clinical)
Psychiatry and Mental health
Biological Psychiatry

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10.1097/01.ypg.0000218619.50386.7c

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Ivo, R., Schulze, T. G., Schumacher, J., Kesper, K., Müller, D. J., Kremer, I., Dobrusin, M., Mujaheed, M., Murad, I., Blanaru, M., Bannoura, I., Reshef, A., Bachner-Melman, R., Ebstein, R. P., Propping, P., Belmaker, R. H., Maier, W., Rietschel, M., Nöthen, M. M., & Cichon, S. (2006). No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis. Psychiatric Genetics, 16(5), 197-203. https://doi.org/10.1097/01.ypg.0000218619.50386.7c

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title = "No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis",

abstract = "OBJECTIVES: An analysis of 80 British parent-offspring trios by Wei and Hemmings in 2000 revealed thre1e out of five markers within the NOTCH4 locus to be strongly associated with schizophrenia. In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin. METHODS: Our study population comprised a German case-control sample (n=512 schizophrenia patients and n=232 controls) and two independent parent-offspring trio samples of German (n=159 trios) and Palestinian-Arab (n=208 trios) descent. We examined a total of ten single nucleotide polymorphisms within the NOTCH4 locus and the adjacent loci, spanning a region of approximately 100 kb. RESULTS: Neither single marker nor haplotype analyses showed association with schizophrenia. In addition, analyses of the German case-control and trio samples revealed no significant association between NOTCH4 polymorphisms and early-onset schizophrenia. CONCLUSIONS: Our results suggest that NOTCH4 is unlikely to play a major role in the genetic predisposition to schizophrenia in the German or the Palestinian-Arab population.",

keywords = "Age of onset, Association analysis, NOTCH4, Schizophrenia, Single nucleotide polymorphism",

author = "Roland Ivo and Schulze, {Thomas G.} and Johannes Schumacher and Kristina Kesper and M{\"u}ller, {Daniel J.} and Ilana Kremer and Michael Dobrusin and Mustafa Mujaheed and Ibrahim Murad and Monika Blanaru and Isaam Bannoura and Alon Reshef and Rachel Bachner-Melman and Ebstein, {Richard P.} and Peter Propping and Belmaker, {Robert H.} and Wolfgang Maier and Marcella Rietschel and N{\"o}then, {Markus M.} and Sven Cichon",

year = "2006",

month = oct,

day = "1",

doi = "10.1097/01.ypg.0000218619.50386.7c",

language = "English",

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Ivo, R, Schulze, TG, Schumacher, J, Kesper, K, Müller, DJ, Kremer, I, Dobrusin, M, Mujaheed, M, Murad, I, Blanaru, M, Bannoura, I, Reshef, A, Bachner-Melman, R, Ebstein, RP, Propping, P, Belmaker, RH, Maier, W, Rietschel, M, Nöthen, MM & Cichon, S 2006, 'No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis', Psychiatric Genetics, vol. 16, no. 5, pp. 197-203. https://doi.org/10.1097/01.ypg.0000218619.50386.7c

TY - JOUR

T1 - No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis

AU - Ivo, Roland

AU - Schulze, Thomas G.

AU - Schumacher, Johannes

AU - Kesper, Kristina

AU - Müller, Daniel J.

AU - Kremer, Ilana

AU - Dobrusin, Michael

AU - Mujaheed, Mustafa

AU - Murad, Ibrahim

AU - Blanaru, Monika

AU - Bannoura, Isaam

AU - Reshef, Alon

AU - Bachner-Melman, Rachel

AU - Ebstein, Richard P.

AU - Propping, Peter

AU - Belmaker, Robert H.

AU - Maier, Wolfgang

AU - Rietschel, Marcella

AU - Nöthen, Markus M.

AU - Cichon, Sven

PY - 2006/10/1

Y1 - 2006/10/1

N2 - OBJECTIVES: An analysis of 80 British parent-offspring trios by Wei and Hemmings in 2000 revealed thre1e out of five markers within the NOTCH4 locus to be strongly associated with schizophrenia. In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin. METHODS: Our study population comprised a German case-control sample (n=512 schizophrenia patients and n=232 controls) and two independent parent-offspring trio samples of German (n=159 trios) and Palestinian-Arab (n=208 trios) descent. We examined a total of ten single nucleotide polymorphisms within the NOTCH4 locus and the adjacent loci, spanning a region of approximately 100 kb. RESULTS: Neither single marker nor haplotype analyses showed association with schizophrenia. In addition, analyses of the German case-control and trio samples revealed no significant association between NOTCH4 polymorphisms and early-onset schizophrenia. CONCLUSIONS: Our results suggest that NOTCH4 is unlikely to play a major role in the genetic predisposition to schizophrenia in the German or the Palestinian-Arab population.

AB - OBJECTIVES: An analysis of 80 British parent-offspring trios by Wei and Hemmings in 2000 revealed thre1e out of five markers within the NOTCH4 locus to be strongly associated with schizophrenia. In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin. METHODS: Our study population comprised a German case-control sample (n=512 schizophrenia patients and n=232 controls) and two independent parent-offspring trio samples of German (n=159 trios) and Palestinian-Arab (n=208 trios) descent. We examined a total of ten single nucleotide polymorphisms within the NOTCH4 locus and the adjacent loci, spanning a region of approximately 100 kb. RESULTS: Neither single marker nor haplotype analyses showed association with schizophrenia. In addition, analyses of the German case-control and trio samples revealed no significant association between NOTCH4 polymorphisms and early-onset schizophrenia. CONCLUSIONS: Our results suggest that NOTCH4 is unlikely to play a major role in the genetic predisposition to schizophrenia in the German or the Palestinian-Arab population.

KW - Age of onset

KW - Association analysis

KW - NOTCH4

KW - Schizophrenia

KW - Single nucleotide polymorphism

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U2 - 10.1097/01.ypg.0000218619.50386.7c

DO - 10.1097/01.ypg.0000218619.50386.7c

M3 - Article

AN - SCOPUS:33748740990

SN - 0955-8829

VL - 16

SP - 197

EP - 203

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 5

ER -

No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis

Abstract

Keywords

ASJC Scopus subject areas

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