No evidence for linkage by transmission disequilibrium test analysis of microsatellite markers in chromosomal 1q21-22 REGION to schizophrenia in a palestinian arab population

R. P. Ebstein, M. Corbex, I. Kremer, M. Dobrusin, I. Murad, M. Rietschel, W. Maier

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Abstract

A recent genome scan in 22 extended families primarily of Celtic origin with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (Lod) score of 6.50. Since schizophrenia is characterized by clinical heterogeneity and likely by genetic heterogeneity, we thought it important to try to further examine chromosome 1q21 region for linkage to schizophrenia in a group of ethnically akin Palestinian Arabs we have been studying. 238 families were genotyped, primarily consisting of one affected proband and both parents, for three microsatellite markers (DIS1677, D1S1679 & D1S1653) that provided the highest Lod scores in the Canadian study. No evidence for linkage using TDT analysis of the three markers to schizophrenia was observed in this population.

Original languageEnglish
Pages (from-to)598
Number of pages1
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume105
Issue number7
StatePublished - 8 Oct 2001
Externally publishedYes

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