Abstract
A recent genome scan in 22 extended families primarily of Celtic origin with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (Lod) score of 6.50. Since schizophrenia is characterized by clinical heterogeneity and likely by genetic heterogeneity, we thought it important to try to further examine chromosome 1q21 region for linkage to schizophrenia in a group of ethnically akin Palestinian Arabs we have been studying. 238 families were genotyped, primarily consisting of one affected proband and both parents, for three microsatellite markers (DIS1677, D1S1679 & D1S1653) that provided the highest Lod scores in the Canadian study. No evidence for linkage using TDT analysis of the three markers to schizophrenia was observed in this population.
| Original language | English |
|---|---|
| Pages (from-to) | 598 |
| Number of pages | 1 |
| Journal | American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics |
| Volume | 105 |
| Issue number | 7 |
| State | Published - 8 Oct 2001 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics(clinical)
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience