No gross abnormality of plasma homocysteine after acute methionine loading in clinically stabilized patients with schizophrenia

Nurit Shlafman, Svetlana Shaldubin, Julia Applebaum, R. H. Belmaker, Joseph Levine

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations

    Abstract

    Homocysteine is reported to be a risk factor for schizophrenia. The methionine loading test evaluates the summation of a multitude of enzymatic pathways associated with homocysteine metabolism. Using a challenge paradigm, we measured homocysteine levels in 10 chronic schizophrenia patients and five controls at baseline and 3 h after 100 mg/kg oral methionine. This pilot study failed to detect a gross abnormality of plasma homocysteine level after acute methionine load in patients with schizophrenia. Elevations in plasma homocysteine reported in schizophrenia do not derive from a dynamic abnormality in methionine metabolism in this challenge paradigm.

    Original languageEnglish
    Pages (from-to)64-66
    Number of pages3
    JournalAsian Journal of Psychiatry
    Volume3
    Issue number2
    DOIs
    StatePublished - 1 Jun 2010

    Keywords

    • Homocysteine
    • Methionine load
    • Schizophrenia

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