Non-synchronized endometrium and its correction in non-ovulatory cryopreserved embryo transfer cycles

Hala Gomaa, Robert F. Casper, Navid Esfandiari, Yaakov Bentov

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The aim of this case series study was to investigate the effect of adjusting the length of progesterone exposure on clinical pregnancy rates in cryopreserved embryo transfer cycles of patients with out-of-phase classic endometrial dating. Eighty infertile women with previous implantation failure and good-quality embryos underwent endometrial biopsy before cryopreserved embryo transfer and were included in this study. The main outcome measures were clinical pregnancy rate and histologic endometrial dating. After adjusting the length of progesterone exposure according to endometrial dating, a significantly higher implantation rate was observed in blastocyst transfers (P = 0.02) and the clinical pregnancy rate for all cycles was 36.4%, similar to that in patients with in-phase endometrium (22.5%). In conclusion, the use of classic histologic endometrial dating to estimate the timing of the window of implantation and to adjust progesterone exposure accordingly may increase the implantation rate in frozen embryo transfer cycles.

Original languageEnglish
Pages (from-to)378-384
Number of pages7
JournalReproductive BioMedicine Online
Issue number4
StatePublished - 1 Apr 2015
Externally publishedYes


  • cryopreserved embryo transfer
  • endometrial dating
  • pregnancy
  • window of implantation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology


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