Nonlinear analysis of RR interval in euthymic bipolar disorder

D. Todder, Y. Bersudsky, H. Cohen

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22 Scopus citations


The bipolar affective disorder is long been speculated to have an autonomic involvement. Nonlinear analysis of heart rate variability has recently been shown to be a reliable noninvasive test for quantitative assessment of the central sympathovagal interaction that modulates cardiovascular autonomic function. We studied 32 euthymic bipolar patients and 24 controls. A high-resolution electrocardiogram was obtained during complete rest. Nonlinear analysis (Poincare plot, largest Lyaponuv exponent, minimal embedding dimension, symbolic dynamic) was used. There wasn't a statistically significant difference in the nonlinear analysis of the heart rate variability, between the euthymic bipolar patients and controls, in the rest situation. The nonlinear analysis of heart rate variability didn't support the notation that there is a disturbance in the autonomic nerves system of bipolar patients in the euthymic state.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalAutonomic Neuroscience: Basic and Clinical
Issue number2
StatePublished - 7 Feb 2005
Externally publishedYes


  • Autonomic nervous system
  • Bipolar disorder
  • Chaos theory
  • Heart rate variability
  • Nonlinear analysis


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