Nonlinkage of the t cell receptor α, β, and γ genes to systemic lupus erythematosus in multiplex families

David W. Wong, Zvi Bentwich, Carlos Martinez‐Tarquino, J. G. Seidman, Allan D. Duby, Thomas Quertermous, Peter H. Schur

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

To test the possibility that T cell antigen receptor (TcR) genes are linked to the genes involved in the pathogenesis of systemic lupus erythematosus (SLE), genomic DNA restriction fragment length polymorphisms were studied, using the Southern blot technique, in 5 families with multiple members with SLE, 14 unrelated SLE patients, and 14 normal controls. Polymorphic patterns were detected with probes for all 3 TcR chains, but there was no significant difference in the distribution of the restriction fragment length polymorphism pattern among the patients, the relatives, and the controls. Furthermore, in the families with at least 2 individuals with the disease, each of the 3 TcR chain genes did not cosegregate with the disease. We conclude that TcRα, β, γ chain genes are not likely to be linked to genes related to SLE.

Original languageEnglish
Pages (from-to)1371-1376
Number of pages6
JournalArthritis and Rheumatology
Volume31
Issue number11
DOIs
StatePublished - 1 Jan 1988
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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