Normal levels and function of endothelial progenitor cells in patients with psoriatic arthritis

Jacob N. Ablin, Zacharinka Goldstein, Valerie Aloush, Hagit Matz, Ori Elkayam, Dan Caspi, Shmuel Swartzenberg, Jacob George, Yonit Wohl

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Endothelial progenitor cells (EPCs) are a population of bone marrow derived cells which have been attributed with the ability to migrate into areas of tissue ischemia and to posses reparative qualities. EPCs have been shown to be decreased in level and function in various inflammatory disorders. Psoriasis and psoriatic arthritis are associated with an increase in cardiovascular morbidity. The aim of the study was to investigate the number of EPCs among patients suffering from psoriasis and psoriatic arthritis. Patients suffering from active psoriasis and psoriatic arthritis were recruited as well as healthy controls. Disease activity was assessed with the DAS-28, BASDAI and PASI scores. Peripheral blood mononuclear cells were isolated and EPC numbers evaluated by FACS analysis using the CD34/133 and CD34/KDR. No significant difference was found between numbers of EPCs between healthy controls, patients with psoriasis and psoriatic arthritis. A significant correlation was found between levels of VGEF and the BASDAI score. The results of the current study do not support a significant role for EPCs in the pathogenesis of psoriasis and psoriatic arthritis.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalRheumatology International
Volume29
Issue number3
DOIs
StatePublished - 1 Jan 2009
Externally publishedYes

Keywords

  • Endothelial progenitor cells (EPCs)
  • Psoriasis
  • Psoriatic arthritis
  • VGEF

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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